[{"abstract":[{"lang":"eng","text":"<jats:title>Abstract</jats:title><jats:p>We consider the problem of maximization of metabolite production in bacterial cells formulated as a dynamical optimal control problem (DOCP). According to Pontryagin’s maximum principle, optimal solutions are concatenations of singular and bang arcs and exhibit the chattering or <jats:italic>Fuller</jats:italic> phenomenon, which is problematic for applications. To avoid chattering, we introduce a reduced model which is still biologically relevant and retains the important structural features of the original problem. Using a combination of analytical and numerical methods, we show that the singular arc is dominant in the studied DOCPs and exhibits the <jats:italic>turnpike</jats:italic> property. This property is further used in order to design simple and realistic suboptimal control strategies.</jats:p>"}],"status":"public","publication":"Journal of Optimization Theory and Applications","type":"journal_article","keyword":["Applied Mathematics","Management Science and Operations Research","Control and Optimization"],"language":[{"iso":"eng"}],"_id":"30861","department":[{"_id":"636"}],"user_id":"87909","year":"2022","citation":{"chicago":"Caillau, Jean-Baptiste, Walid Djema, Jean-Luc Gouzé, Sofya Maslovskaya, and Jean-Baptiste Pomet. “Turnpike Property in Optimal Microbial Metabolite Production.” <i>Journal of Optimization Theory and Applications</i>, 2022. <a href=\"https://doi.org/10.1007/s10957-022-02023-0\">https://doi.org/10.1007/s10957-022-02023-0</a>.","ieee":"J.-B. Caillau, W. Djema, J.-L. Gouzé, S. Maslovskaya, and J.-B. Pomet, “Turnpike Property in Optimal Microbial Metabolite Production,” <i>Journal of Optimization Theory and Applications</i>, 2022, doi: <a href=\"https://doi.org/10.1007/s10957-022-02023-0\">10.1007/s10957-022-02023-0</a>.","ama":"Caillau J-B, Djema W, Gouzé J-L, Maslovskaya S, Pomet J-B. Turnpike Property in Optimal Microbial Metabolite Production. <i>Journal of Optimization Theory and Applications</i>. Published online 2022. doi:<a href=\"https://doi.org/10.1007/s10957-022-02023-0\">10.1007/s10957-022-02023-0</a>","bibtex":"@article{Caillau_Djema_Gouzé_Maslovskaya_Pomet_2022, title={Turnpike Property in Optimal Microbial Metabolite Production}, DOI={<a href=\"https://doi.org/10.1007/s10957-022-02023-0\">10.1007/s10957-022-02023-0</a>}, journal={Journal of Optimization Theory and Applications}, publisher={Springer Science and Business Media LLC}, author={Caillau, Jean-Baptiste and Djema, Walid and Gouzé, Jean-Luc and Maslovskaya, Sofya and Pomet, Jean-Baptiste}, year={2022} }","short":"J.-B. Caillau, W. Djema, J.-L. Gouzé, S. Maslovskaya, J.-B. Pomet, Journal of Optimization Theory and Applications (2022).","mla":"Caillau, Jean-Baptiste, et al. “Turnpike Property in Optimal Microbial Metabolite Production.” <i>Journal of Optimization Theory and Applications</i>, Springer Science and Business Media LLC, 2022, doi:<a href=\"https://doi.org/10.1007/s10957-022-02023-0\">10.1007/s10957-022-02023-0</a>.","apa":"Caillau, J.-B., Djema, W., Gouzé, J.-L., Maslovskaya, S., &#38; Pomet, J.-B. (2022). Turnpike Property in Optimal Microbial Metabolite Production. <i>Journal of Optimization Theory and Applications</i>. <a href=\"https://doi.org/10.1007/s10957-022-02023-0\">https://doi.org/10.1007/s10957-022-02023-0</a>"},"publication_identifier":{"issn":["0022-3239","1573-2878"]},"publication_status":"published","title":"Turnpike Property in Optimal Microbial Metabolite Production","doi":"10.1007/s10957-022-02023-0","date_updated":"2022-04-08T18:23:02Z","publisher":"Springer Science and Business Media LLC","date_created":"2022-04-08T17:23:13Z","author":[{"full_name":"Caillau, Jean-Baptiste","last_name":"Caillau","first_name":"Jean-Baptiste"},{"last_name":"Djema","full_name":"Djema, Walid","first_name":"Walid"},{"last_name":"Gouzé","full_name":"Gouzé, Jean-Luc","first_name":"Jean-Luc"},{"last_name":"Maslovskaya","id":"87909","full_name":"Maslovskaya, Sofya","first_name":"Sofya"},{"last_name":"Pomet","full_name":"Pomet, Jean-Baptiste","first_name":"Jean-Baptiste"}]}]