---
_id: '32323'
abstract:
- lang: eng
text: Genetic correlations suggest a coexisting genetic predisposition to
both low leptin levels and risk for anorexia nervosa (AN). To investigate the
causality and direction of these associations, we performed bidirectional two-sample
Mendelian randomization (MR) analyses using data of the most recent genome-wide
association study (GWAS) for AN and both a GWAS and an exome-wide-association-study
(EWAS) for leptin levels. Most MR methods with genetic instruments from GWAS showed
a causal effect of lower leptin levels on higher risk of AN (e.g. IVW b = −0.923,
p = 1.5 × 10−4). Because most
patients with AN are female, we additionally performed analyses using leptin GWAS
data of females only. Again, there was a significant effect of leptin levels on
the risk of AN (e.g. IVW b = −0.826, p = 1.1 × 10−04).
MR with genetic instruments from EWAS showed no overall effect of leptin levels
on the risk for AN. For the opposite direction, MR revealed no causal effect of
AN on leptin levels. If our results are confirmed in extended GWAS data sets,
a low endogenous leptin synthesis represents a risk factor for developing AN.
author:
- first_name: Triinu
full_name: Peters, Triinu
last_name: Peters
- first_name: Jochen
full_name: Antel, Jochen
last_name: Antel
- first_name: Roaa
full_name: Naaresh, Roaa
last_name: Naaresh
- first_name: Björn-Hergen
full_name: Laabs, Björn-Hergen
last_name: Laabs
- first_name: Manuel
full_name: Föcker, Manuel
last_name: Föcker
- first_name: Nicola
full_name: Albers, Nicola
last_name: Albers
- first_name: Judith
full_name: Bühlmeier, Judith
last_name: Bühlmeier
- first_name: Anke
full_name: Hinney, Anke
last_name: Hinney
- first_name: Lars
full_name: Libuda, Lars
last_name: Libuda
- first_name: Johannes
full_name: Hebebrand, Johannes
last_name: Hebebrand
citation:
ama: 'Peters T, Antel J, Naaresh R, et al. Suggestive Evidence for Causal Effect
of Leptin Levels on Risk for Anorexia Nervosa: Results of a Mendelian Randomization
Study. Frontiers in Genetics. 2021;12. doi:10.3389/fgene.2021.733606'
apa: 'Peters, T., Antel, J., Naaresh, R., Laabs, B.-H., Föcker, M., Albers, N.,
Bühlmeier, J., Hinney, A., Libuda, L., & Hebebrand, J. (2021). Suggestive
Evidence for Causal Effect of Leptin Levels on Risk for Anorexia Nervosa: Results
of a Mendelian Randomization Study. Frontiers in Genetics, 12. https://doi.org/10.3389/fgene.2021.733606'
bibtex: '@article{Peters_Antel_Naaresh_Laabs_Föcker_Albers_Bühlmeier_Hinney_Libuda_Hebebrand_2021,
title={Suggestive Evidence for Causal Effect of Leptin Levels on Risk for Anorexia
Nervosa: Results of a Mendelian Randomization Study}, volume={12}, DOI={10.3389/fgene.2021.733606},
journal={Frontiers in Genetics}, publisher={Frontiers Media SA}, author={Peters,
Triinu and Antel, Jochen and Naaresh, Roaa and Laabs, Björn-Hergen and Föcker,
Manuel and Albers, Nicola and Bühlmeier, Judith and Hinney, Anke and Libuda, Lars
and Hebebrand, Johannes}, year={2021} }'
chicago: 'Peters, Triinu, Jochen Antel, Roaa Naaresh, Björn-Hergen Laabs, Manuel
Föcker, Nicola Albers, Judith Bühlmeier, Anke Hinney, Lars Libuda, and Johannes
Hebebrand. “Suggestive Evidence for Causal Effect of Leptin Levels on Risk for
Anorexia Nervosa: Results of a Mendelian Randomization Study.” Frontiers in
Genetics 12 (2021). https://doi.org/10.3389/fgene.2021.733606.'
ieee: 'T. Peters et al., “Suggestive Evidence for Causal Effect of Leptin
Levels on Risk for Anorexia Nervosa: Results of a Mendelian Randomization Study,”
Frontiers in Genetics, vol. 12, 2021, doi: 10.3389/fgene.2021.733606.'
mla: 'Peters, Triinu, et al. “Suggestive Evidence for Causal Effect of Leptin Levels
on Risk for Anorexia Nervosa: Results of a Mendelian Randomization Study.” Frontiers
in Genetics, vol. 12, Frontiers Media SA, 2021, doi:10.3389/fgene.2021.733606.'
short: T. Peters, J. Antel, R. Naaresh, B.-H. Laabs, M. Föcker, N. Albers, J. Bühlmeier,
A. Hinney, L. Libuda, J. Hebebrand, Frontiers in Genetics 12 (2021).
date_created: 2022-07-06T15:10:40Z
date_updated: 2022-08-30T13:11:49Z
department:
- _id: '35'
doi: 10.3389/fgene.2021.733606
intvolume: ' 12'
keyword:
- Genetics (clinical)
- Genetics
- Molecular Medicine
language:
- iso: eng
publication: Frontiers in Genetics
publication_identifier:
issn:
- 1664-8021
publication_status: published
publisher: Frontiers Media SA
status: public
title: 'Suggestive Evidence for Causal Effect of Leptin Levels on Risk for Anorexia
Nervosa: Results of a Mendelian Randomization Study'
type: journal_article
user_id: '88682'
volume: 12
year: '2021'
...