[{"publication":"Journal of Applied Physiology","abstract":[{"text":"<jats:p>We examined, in immobilization, the effect of a diet high in sodium chloride (NaCl) on bone markers, nitrogen balance, and acid-base status. Eight healthy male test subjects participated in a 14-day head-down-tilt bed rest (HDBR) study. During the bed rest period they received, in a randomized crossover design, a high (7.7 meq Na<jats:sup>+</jats:sup>/kg body wt per day) and a low (0.7 meq Na<jats:sup>+</jats:sup>/kg body wt per day) NaCl diet. As expected, 24-h excretion of urinary calcium was significantly greater in the high-NaCl-intake HDBR phase than in the low-NaCl-intake HDBR phase ( P &lt; 0.001). High NaCl intake caused a 43–50% greater excretion of the bone resorption markers COOH- (CTX) and NH<jats:sub>2</jats:sub>- (NTX) terminal telopeptide of type I collagen in HDBR than low NaCl in HDBR (CTX/NTX: P &lt; 0.001). Serum concentrations of the bone formation markers bone-specific alkaline phosphatase (bAP) and NH<jats:sub>2</jats:sub>-terminal propeptide of type I procollagen (PINP) were identical in both NaCl intake phases. High NaCl intake led to a more negative nitrogen balance in HDBR ( P &lt; 0.001). Changes were accompanied by increased serum chloride concentration ( P = 0.008), reduced blood bicarbonate ( P = 0.017), and base excess ( P = 0.009) whereas net acid excretion was lower during high than during low NaCl intake in immobilization ( P &lt; 0.001). High NaCl intake during immobilization exacerbates disuse-induced bone and muscle loss by causing further protein wasting and an increase in bone resorption. Changes in the acid-base status, mainly caused by disturbances in electrolyte metabolism, seem to determine NaCl-induced degradation processes.</jats:p>","lang":"eng"}],"language":[{"iso":"eng"}],"keyword":["Physiology (medical)","Physiology"],"issue":"2","year":"2011","date_created":"2022-09-15T09:37:29Z","publisher":"American Physiological Society","title":"High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses","type":"journal_article","status":"public","user_id":"89838","_id":"33400","extern":"1","publication_identifier":{"issn":["8750-7587","1522-1601"]},"publication_status":"published","intvolume":"       111","page":"537-542","citation":{"apa":"Frings-Meuthen, P., Bühlmeier, J., Baecker, N., Stehle, P., Fimmers, R., May, F., Kluge, G., &#38; Heer, M. (2011). High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses. <i>Journal of Applied Physiology</i>, <i>111</i>(2), 537–542. <a href=\"https://doi.org/10.1152/japplphysiol.00454.2011\">https://doi.org/10.1152/japplphysiol.00454.2011</a>","bibtex":"@article{Frings-Meuthen_Bühlmeier_Baecker_Stehle_Fimmers_May_Kluge_Heer_2011, title={High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses}, volume={111}, DOI={<a href=\"https://doi.org/10.1152/japplphysiol.00454.2011\">10.1152/japplphysiol.00454.2011</a>}, number={2}, journal={Journal of Applied Physiology}, publisher={American Physiological Society}, author={Frings-Meuthen, Petra and Bühlmeier, Judith and Baecker, Natalie and Stehle, Peter and Fimmers, Rolf and May, Francisca and Kluge, Goetz and Heer, Martina}, year={2011}, pages={537–542} }","short":"P. Frings-Meuthen, J. Bühlmeier, N. Baecker, P. Stehle, R. Fimmers, F. May, G. Kluge, M. Heer, Journal of Applied Physiology 111 (2011) 537–542.","mla":"Frings-Meuthen, Petra, et al. “High Sodium Chloride Intake Exacerbates Immobilization-Induced Bone Resorption and Protein Losses.” <i>Journal of Applied Physiology</i>, vol. 111, no. 2, American Physiological Society, 2011, pp. 537–42, doi:<a href=\"https://doi.org/10.1152/japplphysiol.00454.2011\">10.1152/japplphysiol.00454.2011</a>.","ama":"Frings-Meuthen P, Bühlmeier J, Baecker N, et al. High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses. <i>Journal of Applied Physiology</i>. 2011;111(2):537-542. doi:<a href=\"https://doi.org/10.1152/japplphysiol.00454.2011\">10.1152/japplphysiol.00454.2011</a>","chicago":"Frings-Meuthen, Petra, Judith Bühlmeier, Natalie Baecker, Peter Stehle, Rolf Fimmers, Francisca May, Goetz Kluge, and Martina Heer. “High Sodium Chloride Intake Exacerbates Immobilization-Induced Bone Resorption and Protein Losses.” <i>Journal of Applied Physiology</i> 111, no. 2 (2011): 537–42. <a href=\"https://doi.org/10.1152/japplphysiol.00454.2011\">https://doi.org/10.1152/japplphysiol.00454.2011</a>.","ieee":"P. Frings-Meuthen <i>et al.</i>, “High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses,” <i>Journal of Applied Physiology</i>, vol. 111, no. 2, pp. 537–542, 2011, doi: <a href=\"https://doi.org/10.1152/japplphysiol.00454.2011\">10.1152/japplphysiol.00454.2011</a>."},"volume":111,"author":[{"full_name":"Frings-Meuthen, Petra","last_name":"Frings-Meuthen","first_name":"Petra"},{"last_name":"Bühlmeier","full_name":"Bühlmeier, Judith","id":"89838","first_name":"Judith"},{"full_name":"Baecker, Natalie","last_name":"Baecker","first_name":"Natalie"},{"first_name":"Peter","last_name":"Stehle","full_name":"Stehle, Peter"},{"first_name":"Rolf","full_name":"Fimmers, Rolf","last_name":"Fimmers"},{"full_name":"May, Francisca","last_name":"May","first_name":"Francisca"},{"full_name":"Kluge, Goetz","last_name":"Kluge","first_name":"Goetz"},{"full_name":"Heer, Martina","last_name":"Heer","first_name":"Martina"}],"date_updated":"2022-09-15T09:43:45Z","doi":"10.1152/japplphysiol.00454.2011"}]