---
res:
  bibo_abstract:
  - <jats:title>Abstract</jats:title><jats:p>The facile synthesis of highly functionalized
    building blocks with potential biological activity is of great interest to medicinal
    chemistry. The benzoxepinone core structures commonly exhibit biological activity.
    Thus, a short and efficient synthetic route towards benzoxepine containing scaffold,
    which enables late stage modification was developed. Namely, base-free catalytic
    Wittig reactions enabled the synthesis of bromobenzoxepinones from readily available
    starting materials. Subsequent, Suzuki–Miyaura and Stille reactions proved to
    be suitable methods to access a variety of benzoxepinone diaryl derivatives by
    late stage modification in only three steps. This three-step reaction sequence
    is suitable for high throughput applications and gives facile access to highly
    complex molecular structures, which are suitable for further functionalization.
    The antiproliferative properties of selected arylbenzoxepinones­ were tested in
    vitro on monolayer tumor cell line A549. Notably, in this initial screening, these
    compounds were found to be active in the micromolar range.</jats:p>@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Thomas
      foaf_name: Werner, Thomas
      foaf_surname: Werner
      foaf_workInfoHomepage: http://www.librecat.org/personId=89271
    orcid: 0000-0001-9025-3244
  - foaf_Person:
      foaf_givenName: Aiga
      foaf_name: Grandane, Aiga
      foaf_surname: Grandane
  - foaf_Person:
      foaf_givenName: Linda
      foaf_name: Pudnika, Linda
      foaf_surname: Pudnika
  - foaf_Person:
      foaf_givenName: Ilona
      foaf_name: Domraceva, Ilona
      foaf_surname: Domraceva
  - foaf_Person:
      foaf_givenName: Raivis
      foaf_name: Zalubovskis, Raivis
      foaf_surname: Zalubovskis
  bibo_doi: 10.1055/a-1509-6078
  bibo_issue: '19'
  bibo_volume: 53
  dct_date: 2021^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/0039-7881
  - http://id.crossref.org/issn/1437-210X
  dct_language: eng
  dct_publisher: Georg Thieme Verlag KG@
  dct_subject:
  - T2
  - T4
  - CSSD
  dct_title: Base-Free Catalytic Wittig-/Cross-Coupling Reaction Sequence as Short
    Synthetic Strategy for the Preparation of Highly Functionalized Arylbenzoxepinones@
...