{"publication":"Synthesis","page":"3545-3554","language":[{"iso":"eng"}],"citation":{"mla":"Werner, Thomas, et al. “Base-Free Catalytic Wittig-/Cross-Coupling Reaction Sequence as Short Synthetic Strategy for the Preparation of Highly Functionalized Arylbenzoxepinones.” <i>Synthesis</i>, vol. 53, no. 19, Georg Thieme Verlag KG, 2021, pp. 3545–54, doi:<a href=\"https://doi.org/10.1055/a-1509-6078\">10.1055/a-1509-6078</a>.","chicago":"Werner, Thomas, Aiga Grandane, Linda Pudnika, Ilona Domraceva, and Raivis Zalubovskis. “Base-Free Catalytic Wittig-/Cross-Coupling Reaction Sequence as Short Synthetic Strategy for the Preparation of Highly Functionalized Arylbenzoxepinones.” <i>Synthesis</i> 53, no. 19 (2021): 3545–54. <a href=\"https://doi.org/10.1055/a-1509-6078\">https://doi.org/10.1055/a-1509-6078</a>.","apa":"Werner, T., Grandane, A., Pudnika, L., Domraceva, I., &#38; Zalubovskis, R. (2021). Base-Free Catalytic Wittig-/Cross-Coupling Reaction Sequence as Short Synthetic Strategy for the Preparation of Highly Functionalized Arylbenzoxepinones. <i>Synthesis</i>, <i>53</i>(19), 3545–3554. <a href=\"https://doi.org/10.1055/a-1509-6078\">https://doi.org/10.1055/a-1509-6078</a>","short":"T. Werner, A. Grandane, L. Pudnika, I. Domraceva, R. Zalubovskis, Synthesis 53 (2021) 3545–3554.","bibtex":"@article{Werner_Grandane_Pudnika_Domraceva_Zalubovskis_2021, title={Base-Free Catalytic Wittig-/Cross-Coupling Reaction Sequence as Short Synthetic Strategy for the Preparation of Highly Functionalized Arylbenzoxepinones}, volume={53}, DOI={<a href=\"https://doi.org/10.1055/a-1509-6078\">10.1055/a-1509-6078</a>}, number={19}, journal={Synthesis}, publisher={Georg Thieme Verlag KG}, author={Werner, Thomas and Grandane, Aiga and Pudnika, Linda and Domraceva, Ilona and Zalubovskis, Raivis}, year={2021}, pages={3545–3554} }","ieee":"T. Werner, A. Grandane, L. Pudnika, I. Domraceva, and R. Zalubovskis, “Base-Free Catalytic Wittig-/Cross-Coupling Reaction Sequence as Short Synthetic Strategy for the Preparation of Highly Functionalized Arylbenzoxepinones,” <i>Synthesis</i>, vol. 53, no. 19, pp. 3545–3554, 2021, doi: <a href=\"https://doi.org/10.1055/a-1509-6078\">10.1055/a-1509-6078</a>.","ama":"Werner T, Grandane A, Pudnika L, Domraceva I, Zalubovskis R. Base-Free Catalytic Wittig-/Cross-Coupling Reaction Sequence as Short Synthetic Strategy for the Preparation of Highly Functionalized Arylbenzoxepinones. <i>Synthesis</i>. 2021;53(19):3545-3554. doi:<a href=\"https://doi.org/10.1055/a-1509-6078\">10.1055/a-1509-6078</a>"},"publisher":"Georg Thieme Verlag KG","keyword":["Organic Chemistry","Catalysis"],"type":"journal_article","year":"2021","user_id":"14931","_id":"37946","status":"public","abstract":[{"text":"<jats:title>Abstract</jats:title><jats:p>The facile synthesis of highly functionalized building blocks with potential biological activity is of great interest to medicinal chemistry. The benzoxepinone core structures commonly exhibit biological activity. Thus, a short and efficient synthetic route towards benzoxepine containing scaffold, which enables late stage modification was developed. Namely, base-free catalytic Wittig reactions enabled the synthesis of bromobenzoxepinones from readily available starting materials. Subsequent, Suzuki–Miyaura and Stille reactions proved to be suitable methods to access a variety of benzoxepinone diaryl derivatives by late stage modification in only three steps. This three-step reaction sequence is suitable for high throughput applications and gives facile access to highly complex molecular structures, which are suitable for further functionalization. The antiproliferative properties of selected arylbenzoxepinones­ were tested in vitro on monolayer tumor cell line A549. Notably, in this initial screening, these compounds were found to be active in the micromolar range.</jats:p>","lang":"eng"}],"title":"Base-Free Catalytic Wittig-/Cross-Coupling Reaction Sequence as Short Synthetic Strategy for the Preparation of Highly Functionalized Arylbenzoxepinones","date_updated":"2023-01-23T10:44:04Z","intvolume":"        53","issue":"19","department":[{"_id":"35"},{"_id":"2"},{"_id":"657"}],"volume":53,"author":[{"first_name":"Thomas","id":"89271","full_name":"Werner, Thomas","last_name":"Werner"},{"first_name":"Aiga","full_name":"Grandane, Aiga","last_name":"Grandane"},{"first_name":"Linda","last_name":"Pudnika","full_name":"Pudnika, Linda"},{"first_name":"Ilona","full_name":"Domraceva, Ilona","last_name":"Domraceva"},{"full_name":"Zalubovskis, Raivis","last_name":"Zalubovskis","first_name":"Raivis"}],"publication_identifier":{"issn":["0039-7881","1437-210X"]},"doi":"10.1055/a-1509-6078","date_created":"2023-01-22T20:27:34Z","publication_status":"published"}