{"abstract":[{"text":"A previous follow-up of the GINIplus study showed that breastfeeding could protect against early eczema. However, effects diminished in adolescence, possibly indicating a “rebound effect” in breastfed children after initial protection. We evaluated the role of early eczema until three years of age on allergies until young adulthood and assessed whether early eczema modifies the association between breastfeeding and allergies. Data from GINIplus until 20-years of age (N = 4058) were considered. Information on atopic eczema, asthma, and rhinitis was based on reported physician’s diagnoses. Adjusted Odds Ratios (aOR) were modelled by using generalized estimating equations. Early eczema was associated with eczema (aORs = 3.2–14.4), asthma (aORs = 2.2–2.7), and rhinitis (aORs = 1.2–2.7) until young adulthood. For eczema, this association decreased with age (p-for-interaction = 0.002–0.006). Longitudinal models did not show associations between breastfeeding and the respective allergies from 5 to 20 years of age. Moreover, early eczema generally did not modify the association between milk feeding and allergies except for rhinitis in participants without family history of atopy. Early eczema strongly predicts allergies until young adulthood. While preventive effects of full breastfeeding on eczema in infants with family history of atopy does not persist until young adulthood, the hypothesis of a rebound effect after initial protection cannot be confirmed.","lang":"eng"}],"publication":"Nutrients","title":"Full Breastfeeding and Allergic Diseases—Long-Term Protection or Rebound Effects?","volume":15,"publication_status":"published","doi":"10.3390/nu15122780","article_number":"2780","citation":{"bibtex":"@article{Libuda_Filipiak-Pittroff_Standl_Schikowski_von Berg_Koletzko_Bauer_Heinrich_Berdel_Gappa_2023, title={Full Breastfeeding and Allergic Diseases—Long-Term Protection or Rebound Effects?}, volume={15}, DOI={10.3390/nu15122780}, number={122780}, journal={Nutrients}, publisher={MDPI AG}, author={Libuda, Lars and Filipiak-Pittroff, Birgit and Standl, Marie and Schikowski, Tamara and von Berg, Andrea and Koletzko, Sibylle and Bauer, Carl-Peter and Heinrich, Joachim and Berdel, Dietrich and Gappa, Monika}, year={2023} }","apa":"Libuda, L., Filipiak-Pittroff, B., Standl, M., Schikowski, T., von Berg, A., Koletzko, S., Bauer, C.-P., Heinrich, J., Berdel, D., & Gappa, M. (2023). Full Breastfeeding and Allergic Diseases—Long-Term Protection or Rebound Effects? Nutrients, 15(12), Article 2780. https://doi.org/10.3390/nu15122780","mla":"Libuda, Lars, et al. “Full Breastfeeding and Allergic Diseases—Long-Term Protection or Rebound Effects?” Nutrients, vol. 15, no. 12, 2780, MDPI AG, 2023, doi:10.3390/nu15122780.","ieee":"L. Libuda et al., “Full Breastfeeding and Allergic Diseases—Long-Term Protection or Rebound Effects?,” Nutrients, vol. 15, no. 12, Art. no. 2780, 2023, doi: 10.3390/nu15122780.","ama":"Libuda L, Filipiak-Pittroff B, Standl M, et al. Full Breastfeeding and Allergic Diseases—Long-Term Protection or Rebound Effects? Nutrients. 2023;15(12). doi:10.3390/nu15122780","chicago":"Libuda, Lars, Birgit Filipiak-Pittroff, Marie Standl, Tamara Schikowski, Andrea von Berg, Sibylle Koletzko, Carl-Peter Bauer, Joachim Heinrich, Dietrich Berdel, and Monika Gappa. “Full Breastfeeding and Allergic Diseases—Long-Term Protection or Rebound Effects?” Nutrients 15, no. 12 (2023). https://doi.org/10.3390/nu15122780.","short":"L. Libuda, B. Filipiak-Pittroff, M. Standl, T. Schikowski, A. von Berg, S. Koletzko, C.-P. Bauer, J. Heinrich, D. Berdel, M. Gappa, Nutrients 15 (2023)."},"intvolume":" 15","user_id":"88682","status":"public","date_created":"2023-06-29T07:53:51Z","date_updated":"2023-06-29T07:54:27Z","department":[{"_id":"35"},{"_id":"17"},{"_id":"22"}],"publisher":"MDPI AG","type":"journal_article","_id":"45813","publication_identifier":{"issn":["2072-6643"]},"language":[{"iso":"eng"}],"year":"2023","author":[{"id":"88682","full_name":"Libuda, Lars","last_name":"Libuda","first_name":"Lars","orcid":"0000-0003-1603-3133"},{"full_name":"Filipiak-Pittroff, Birgit","last_name":"Filipiak-Pittroff","first_name":"Birgit"},{"full_name":"Standl, Marie","last_name":"Standl","first_name":"Marie"},{"last_name":"Schikowski","full_name":"Schikowski, Tamara","first_name":"Tamara"},{"first_name":"Andrea","full_name":"von Berg, Andrea","last_name":"von Berg"},{"last_name":"Koletzko","full_name":"Koletzko, Sibylle","first_name":"Sibylle"},{"last_name":"Bauer","full_name":"Bauer, Carl-Peter","first_name":"Carl-Peter"},{"first_name":"Joachim","last_name":"Heinrich","full_name":"Heinrich, Joachim"},{"first_name":"Dietrich","last_name":"Berdel","full_name":"Berdel, Dietrich"},{"first_name":"Monika","full_name":"Gappa, Monika","last_name":"Gappa"}],"keyword":["Food Science","Nutrition and Dietetics"],"issue":"12"}