---
_id: '45813'
abstract:
- lang: eng
  text: <jats:p>A previous follow-up of the GINIplus study showed that breastfeeding
    could protect against early eczema. However, effects diminished in adolescence,
    possibly indicating a “rebound effect” in breastfed children after initial protection.
    We evaluated the role of early eczema until three years of age on allergies until
    young adulthood and assessed whether early eczema modifies the association between
    breastfeeding and allergies. Data from GINIplus until 20-years of age (N = 4058)
    were considered. Information on atopic eczema, asthma, and rhinitis was based
    on reported physician’s diagnoses. Adjusted Odds Ratios (aOR) were modelled by
    using generalized estimating equations. Early eczema was associated with eczema
    (aORs = 3.2–14.4), asthma (aORs = 2.2–2.7), and rhinitis (aORs = 1.2–2.7) until
    young adulthood. For eczema, this association decreased with age (p-for-interaction
    = 0.002–0.006). Longitudinal models did not show associations between breastfeeding
    and the respective allergies from 5 to 20 years of age. Moreover, early eczema
    generally did not modify the association between milk feeding and allergies except
    for rhinitis in participants without family history of atopy. Early eczema strongly
    predicts allergies until young adulthood. While preventive effects of full breastfeeding
    on eczema in infants with family history of atopy does not persist until young
    adulthood, the hypothesis of a rebound effect after initial protection cannot
    be confirmed.</jats:p>
article_number: '2780'
author:
- first_name: Lars
  full_name: Libuda, Lars
  id: '88682'
  last_name: Libuda
  orcid: 0000-0003-1603-3133
- first_name: Birgit
  full_name: Filipiak-Pittroff, Birgit
  last_name: Filipiak-Pittroff
- first_name: Marie
  full_name: Standl, Marie
  last_name: Standl
- first_name: Tamara
  full_name: Schikowski, Tamara
  last_name: Schikowski
- first_name: Andrea
  full_name: von Berg, Andrea
  last_name: von Berg
- first_name: Sibylle
  full_name: Koletzko, Sibylle
  last_name: Koletzko
- first_name: Carl-Peter
  full_name: Bauer, Carl-Peter
  last_name: Bauer
- first_name: Joachim
  full_name: Heinrich, Joachim
  last_name: Heinrich
- first_name: Dietrich
  full_name: Berdel, Dietrich
  last_name: Berdel
- first_name: Monika
  full_name: Gappa, Monika
  last_name: Gappa
citation:
  ama: Libuda L, Filipiak-Pittroff B, Standl M, et al. Full Breastfeeding and Allergic
    Diseases—Long-Term Protection or Rebound Effects? <i>Nutrients</i>. 2023;15(12).
    doi:<a href="https://doi.org/10.3390/nu15122780">10.3390/nu15122780</a>
  apa: Libuda, L., Filipiak-Pittroff, B., Standl, M., Schikowski, T., von Berg, A.,
    Koletzko, S., Bauer, C.-P., Heinrich, J., Berdel, D., &#38; Gappa, M. (2023).
    Full Breastfeeding and Allergic Diseases—Long-Term Protection or Rebound Effects?
    <i>Nutrients</i>, <i>15</i>(12), Article 2780. <a href="https://doi.org/10.3390/nu15122780">https://doi.org/10.3390/nu15122780</a>
  bibtex: '@article{Libuda_Filipiak-Pittroff_Standl_Schikowski_von Berg_Koletzko_Bauer_Heinrich_Berdel_Gappa_2023,
    title={Full Breastfeeding and Allergic Diseases—Long-Term Protection or Rebound
    Effects?}, volume={15}, DOI={<a href="https://doi.org/10.3390/nu15122780">10.3390/nu15122780</a>},
    number={122780}, journal={Nutrients}, publisher={MDPI AG}, author={Libuda, Lars
    and Filipiak-Pittroff, Birgit and Standl, Marie and Schikowski, Tamara and von
    Berg, Andrea and Koletzko, Sibylle and Bauer, Carl-Peter and Heinrich, Joachim
    and Berdel, Dietrich and Gappa, Monika}, year={2023} }'
  chicago: Libuda, Lars, Birgit Filipiak-Pittroff, Marie Standl, Tamara Schikowski,
    Andrea von Berg, Sibylle Koletzko, Carl-Peter Bauer, Joachim Heinrich, Dietrich
    Berdel, and Monika Gappa. “Full Breastfeeding and Allergic Diseases—Long-Term
    Protection or Rebound Effects?” <i>Nutrients</i> 15, no. 12 (2023). <a href="https://doi.org/10.3390/nu15122780">https://doi.org/10.3390/nu15122780</a>.
  ieee: 'L. Libuda <i>et al.</i>, “Full Breastfeeding and Allergic Diseases—Long-Term
    Protection or Rebound Effects?,” <i>Nutrients</i>, vol. 15, no. 12, Art. no. 2780,
    2023, doi: <a href="https://doi.org/10.3390/nu15122780">10.3390/nu15122780</a>.'
  mla: Libuda, Lars, et al. “Full Breastfeeding and Allergic Diseases—Long-Term Protection
    or Rebound Effects?” <i>Nutrients</i>, vol. 15, no. 12, 2780, MDPI AG, 2023, doi:<a
    href="https://doi.org/10.3390/nu15122780">10.3390/nu15122780</a>.
  short: L. Libuda, B. Filipiak-Pittroff, M. Standl, T. Schikowski, A. von Berg, S.
    Koletzko, C.-P. Bauer, J. Heinrich, D. Berdel, M. Gappa, Nutrients 15 (2023).
date_created: 2023-06-29T07:53:51Z
date_updated: 2023-06-29T07:54:27Z
department:
- _id: '35'
- _id: '17'
- _id: '22'
doi: 10.3390/nu15122780
intvolume: '        15'
issue: '12'
keyword:
- Food Science
- Nutrition and Dietetics
language:
- iso: eng
publication: Nutrients
publication_identifier:
  issn:
  - 2072-6643
publication_status: published
publisher: MDPI AG
status: public
title: Full Breastfeeding and Allergic Diseases—Long-Term Protection or Rebound Effects?
type: journal_article
user_id: '88682'
volume: 15
year: '2023'
...