The association between dairy intake in adolescents with inflammation and risk markers of type 2 diabetes during young adulthood

article The association between dairy intake in adolescents with inflammation and risk markers of type 2 diabetes during young adulthood – results of the DONALD study published E Hohoff author N Jankovic author I Perrar author ME Schnermann author C Herder author U Nöthlings author Lars Libuda author 886820000-0003-1603-3133 U Alexy author 35 department 17 department 22 department ABSTRACT OBJECTIVE: The aim of this analysis was to investigate whether habitual intake of total dairy (TD) or different dairy types (liquid, solid, fermented, not-fermented, low-fat, high-fat, low-sugar and high-sugar dairy) during adolescence is associated with biomarkers of low-grade inflammation as well as risk factors of type 2 diabetes in young adulthood. DESIGN: Multivariable linear regression analyses were used to investigate prospective associations between estimated TD intake as well as intake of different types of dairy and a pro-inflammatory score, based on hsCRP, IL-6, IL-18, leptin and adiponectin, and insulin resistance assessed as HOMA2-IR in an open cohort study. SETTING: Dortmund, Germany PARTICIPANTS: Data from participants (n=375) of the DOrtmund Nutritional and Anthropometric Longitudinally Designed (DONALD) study were included, for whom at least two 3-day weighed dietary records during adolescence (median age: 11 years) and one blood sample in young adulthood (>18 years) were available. RESULTS: There was no statistically significant association between TD intake or intake of any dairy type and the pro-inflammatory score (all p>0.05). TD intake as well as each dairy type intake and insulin resistance also showed no association (all p>0.05). CONCLUSIONS: The habitual intake of dairy or individual types of dairy during adolescence does not seem to have a major impact on low-grade systemic inflammation and insulin resistance in the long term. There was no indication regarding a restriction of dairy intake for healthy children and adolescents in terms of diabetes risk reduction. Cambridge University Press (CUP)2024 eng Public HealthEnvironmental and Occupational HealthNutrition and DieteticsMedicine (miscellaneous) Public Health Nutrition 1368-9800 1475-272710.1017/s1368980024000624 1-26 Hohoff, E., Jankovic, N., Perrar, I., Schnermann, M., Herder, C., Nöthlings, U., Libuda, L., & Alexy, U. (2024). The association between dairy intake in adolescents with inflammation and risk markers of type 2 diabetes during young adulthood – results of the DONALD study. Public Health Nutrition, 1–26. <a href="https://doi.org/10.1017/s1368980024000624">https://doi.org/10.1017/s1368980024000624</a> E. Hohoff, N. Jankovic, I. Perrar, M. Schnermann, C. Herder, U. Nöthlings, L. Libuda, U. Alexy, Public Health Nutrition (2024) 1–26. @article{Hohoff_Jankovic_Perrar_Schnermann_Herder_Nöthlings_Libuda_Alexy_2024, title={The association between dairy intake in adolescents with inflammation and risk markers of type 2 diabetes during young adulthood – results of the DONALD study}, DOI={<a href="https://doi.org/10.1017/s1368980024000624">10.1017/s1368980024000624</a>}, journal={Public Health Nutrition}, publisher={Cambridge University Press (CUP)}, author={Hohoff, E and Jankovic, N and Perrar, I and Schnermann, ME and Herder, C and Nöthlings, U and Libuda, Lars and Alexy, U}, year={2024}, pages={1–26} } Hohoff, E., et al. “The Association between Dairy Intake in Adolescents with Inflammation and Risk Markers of Type 2 Diabetes during Young Adulthood – Results of the DONALD Study.” Public Health Nutrition, Cambridge University Press (CUP), 2024, pp. 1–26, doi:<a href="https://doi.org/10.1017/s1368980024000624">10.1017/s1368980024000624</a>. Hohoff E, Jankovic N, Perrar I, et al. The association between dairy intake in adolescents with inflammation and risk markers of type 2 diabetes during young adulthood – results of the DONALD study. Public Health Nutrition. Published online 2024:1-26. doi:<a href="https://doi.org/10.1017/s1368980024000624">10.1017/s1368980024000624</a> E. Hohoff et al., “The association between dairy intake in adolescents with inflammation and risk markers of type 2 diabetes during young adulthood – results of the DONALD study,” Public Health Nutrition, pp. 1–26, 2024, doi: <a href="https://doi.org/10.1017/s1368980024000624">10.1017/s1368980024000624</a>. Hohoff, E, N Jankovic, I Perrar, ME Schnermann, C Herder, U Nöthlings, Lars Libuda, and U Alexy. “The Association between Dairy Intake in Adolescents with Inflammation and Risk Markers of Type 2 Diabetes during Young Adulthood – Results of the DONALD Study.” Public Health Nutrition, 2024, 1–26. <a href="https://doi.org/10.1017/s1368980024000624">https://doi.org/10.1017/s1368980024000624</a>. 527132024-03-21T14:58:10Z2024-04-25T09:49:44Z