---
_id: '53170'
abstract:
- lang: eng
  text: <jats:title>Abstract</jats:title><jats:p>Coating medical implants with antibacterial
    polymers may prevent postoperative infections which are a common issue for conventional
    titanium implants and can even lead to implant failure. Easily applicable diblock
    copolymers are presented that form polymer brushes via “grafting to” mechanism
    on titanium and equip the modified material with antibacterial properties. The
    polymers carry quaternized pyridinium units to combat bacteria and phosphonic
    acid groups which allow the linear chains to be anchored to metal surfaces in
    a convenient coating process. The polymers are synthesized via reversible‐addition‐fragmentation‐chain‐transfer
    (RAFT) polymerization and postmodifications and are characterized using NMR spectroscopy
    and SEC. Low grafting densities are a major drawback of the “grafting to” approach
    compared to “grafting from”. Thus, the number of phosphonic acid groups in the
    anchor block are varied to investigate and optimize the surface binding. Modified
    titanium surfaces are examined regarding their composition, wetting behavior,
    streaming potential, and coating stability. Evaluation of the antimicrobial properties
    revealed reduced bacterial adhesion and biofilm formation for certain polymers,
    albeit the cell biocompatibility against human gingival fibroblasts is also impaired.
    The presented findings show the potential of easy‐to‐apply polymer coatings and
    aid in designing next‐generation implant surface modifications.</jats:p>
article_type: original
author:
- first_name: Rafael
  full_name: Methling, Rafael
  last_name: Methling
- first_name: Oliver
  full_name: Dückmann, Oliver
  last_name: Dückmann
- first_name: Frank
  full_name: Simon, Frank
  last_name: Simon
- first_name: Cornelia
  full_name: Wolf‐Brandstetter, Cornelia
  last_name: Wolf‐Brandstetter
- first_name: Dirk
  full_name: Kuckling, Dirk
  id: '287'
  last_name: Kuckling
citation:
  ama: Methling R, Dückmann O, Simon F, Wolf‐Brandstetter C, Kuckling D. Antimicrobial
    Brushes on Titanium via “Grafting to” Using Phosphonic Acid/Pyridinium Containing
    Block Copolymers. <i>Macromolecular Materials and Engineering</i>. 2023;308(8).
    doi:<a href="https://doi.org/10.1002/mame.202200665">10.1002/mame.202200665</a>
  apa: Methling, R., Dückmann, O., Simon, F., Wolf‐Brandstetter, C., &#38; Kuckling,
    D. (2023). Antimicrobial Brushes on Titanium via “Grafting to” Using Phosphonic
    Acid/Pyridinium Containing Block Copolymers. <i>Macromolecular Materials and Engineering</i>,
    <i>308</i>(8). <a href="https://doi.org/10.1002/mame.202200665">https://doi.org/10.1002/mame.202200665</a>
  bibtex: '@article{Methling_Dückmann_Simon_Wolf‐Brandstetter_Kuckling_2023, title={Antimicrobial
    Brushes on Titanium via “Grafting to” Using Phosphonic Acid/Pyridinium Containing
    Block Copolymers}, volume={308}, DOI={<a href="https://doi.org/10.1002/mame.202200665">10.1002/mame.202200665</a>},
    number={8}, journal={Macromolecular Materials and Engineering}, publisher={Wiley},
    author={Methling, Rafael and Dückmann, Oliver and Simon, Frank and Wolf‐Brandstetter,
    Cornelia and Kuckling, Dirk}, year={2023} }'
  chicago: Methling, Rafael, Oliver Dückmann, Frank Simon, Cornelia Wolf‐Brandstetter,
    and Dirk Kuckling. “Antimicrobial Brushes on Titanium via ‘Grafting to’ Using
    Phosphonic Acid/Pyridinium Containing Block Copolymers.” <i>Macromolecular Materials
    and Engineering</i> 308, no. 8 (2023). <a href="https://doi.org/10.1002/mame.202200665">https://doi.org/10.1002/mame.202200665</a>.
  ieee: 'R. Methling, O. Dückmann, F. Simon, C. Wolf‐Brandstetter, and D. Kuckling,
    “Antimicrobial Brushes on Titanium via ‘Grafting to’ Using Phosphonic Acid/Pyridinium
    Containing Block Copolymers,” <i>Macromolecular Materials and Engineering</i>,
    vol. 308, no. 8, 2023, doi: <a href="https://doi.org/10.1002/mame.202200665">10.1002/mame.202200665</a>.'
  mla: Methling, Rafael, et al. “Antimicrobial Brushes on Titanium via ‘Grafting to’
    Using Phosphonic Acid/Pyridinium Containing Block Copolymers.” <i>Macromolecular
    Materials and Engineering</i>, vol. 308, no. 8, Wiley, 2023, doi:<a href="https://doi.org/10.1002/mame.202200665">10.1002/mame.202200665</a>.
  short: R. Methling, O. Dückmann, F. Simon, C. Wolf‐Brandstetter, D. Kuckling, Macromolecular
    Materials and Engineering 308 (2023).
date_created: 2024-04-03T11:08:51Z
date_updated: 2024-04-03T11:10:05Z
department:
- _id: '163'
doi: 10.1002/mame.202200665
intvolume: '       308'
issue: '8'
keyword:
- Materials Chemistry
- Polymers and Plastics
- Organic Chemistry
- General Chemical Engineering
language:
- iso: eng
publication: Macromolecular Materials and Engineering
publication_identifier:
  issn:
  - 1438-7492
  - 1439-2054
publication_status: published
publisher: Wiley
status: public
title: Antimicrobial Brushes on Titanium via “Grafting to” Using Phosphonic Acid/Pyridinium
  Containing Block Copolymers
type: journal_article
user_id: '94'
volume: 308
year: '2023'
...