---
res:
  bibo_abstract:
  - Incubation of microvascular endothelial cells with combretastatin A-4 phosphate
    (CA-4P), a microtubule-destabilizing compound that preferentially targets tumor
    vessels, altered cell morphology and induced scattering of Golgi stacks. Concomitantly,
    CA-4P up-regulated connective tissue growth factor (CTGF/CCN2), a pleiotropic
    factor with antiangiogenic properties. In contrast to the effects of other microtubule-targeting
    agents such as colchicine or nocodazole, up-regulation of CTGF was only detectable
    in sparse cells, which were not embedded in a cell monolayer. Furthermore, CA-4P
    induced CTGF expression in endothelial cells, forming tube-like structures on
    basement membrane gels. Up-regulation of CTGF by CA-4P was dependent on Rho kinase
    signaling and was increased when p42/44 mitogen-activated protein kinase was inhibited.
    Additionally, FoxO transcription factors were identified as potent regulators
    of CTGF expression in endothelial cells. Activation of FoxO transcription factors
    by inhibition of phosphatidylinositol 3-kinase/AKT signaling resulted in a synergistic
    increase in CA-4P-mediated CTGF induction. CA-4P-mediated expression of CTGF was
    thus potentiated by the inhibition of kinase pathways, which are targets of novel
    antineoplastic drugs. Up-regulation of CTGF by low concentrations of CA-4P may
    thus occur in newly formed tumor vessels and contribute to the microvessel destabilization
    and antiangiogenic effects of CA-4P observed in vivo.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Jana
      foaf_name: Samarin, Jana
      foaf_surname: Samarin
  - foaf_Person:
      foaf_givenName: Margot
      foaf_name: Rehm, Margot
      foaf_surname: Rehm
  - foaf_Person:
      foaf_givenName: Bettina
      foaf_name: Krueger, Bettina
      foaf_surname: Krueger
      foaf_workInfoHomepage: http://www.librecat.org/personId=49428
    orcid: 0000-0001-5351-1785
  - foaf_Person:
      foaf_givenName: Jens
      foaf_name: Waschke, Jens
      foaf_surname: Waschke
  - foaf_Person:
      foaf_givenName: Margarete
      foaf_name: Goppelt-Struebe, Margarete
      foaf_surname: Goppelt-Struebe
  bibo_doi: 10.1158/1541-7786.mcr-08-0292
  bibo_issue: '2'
  bibo_volume: 7
  dct_date: 2009^xs_gYear
  dct_language: eng
  dct_publisher: American Association for Cancer Research (AACR)@
  dct_title: Up-Regulation of Connective Tissue Growth Factor in Endothelial Cells
    by the Microtubule-Destabilizing Agent Combretastatin A-4@
...