---
res:
  bibo_abstract:
  - 'Purpose: The epithelial sodium channel (ENaC) is typically expressed in sodium-absorbing
    epithelia. Several reports suggest that ENaC is also expressed in ocular tissues
    and may play a role in aqueous humor secretion and glaucoma. However, the precise
    localization of ENaC in the human eye is still unclear. Here, the authors studied
    ENaC expression in 12 normal human donor eyes and in six eyes of patients with
    glaucoma. Methods: Quantitative real-time PCR was used to investigate the expression
    of $\alpha$-, $\beta$-, $\gamma$-, and $\delta$-ENaC transcripts in ocular tissues.
    In addition, the authors performed immunohistochemical studies using recently
    generated antibodies against human $\beta$- and $\gamma$-ENaC. Results: At the
    mRNA level, all four ENaC subunits were found to be expressed in a wide range
    of ocular tissues from normal and glaucomatous human eyes, with the cornea, ciliary
    body, iris, and retina showing the highest expression levels. At the protein level,
    $\beta$- and $\gamma$-ENaC subunits showed distinct distribution patterns and
    could be immunolocalized primarily to the cell membranes of epithelial cells of
    the cornea and to the conjunctiva, iris, ciliary body, lens, and retinal pigment
    epithelium but also to vascular endothelial cells, smooth muscle cells, stromal
    cells, and retinal neurons. The authors found no altered mRNA level of any subunit
    in glaucomatous eyes. Conclusions: All four ENaC subunits ($\alpha$$\beta$$\gamma$$\delta$)
    are expressed in the normal human eye, with distinct localization of subunits
    possibly reflecting different functional states of the channel. The (patho-)physiological
    roles of ENaC in the various localizations in the eye remain to be determined.@eng'
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Bettina
      foaf_name: Krueger, Bettina
      foaf_surname: Krueger
      foaf_workInfoHomepage: http://www.librecat.org/personId=49428
    orcid: 0000-0001-5351-1785
  - foaf_Person:
      foaf_givenName: Ursula
      foaf_name: Schlötzer-Schrehardt, Ursula
      foaf_surname: Schlötzer-Schrehardt
  - foaf_Person:
      foaf_givenName: Silke
      foaf_name: Haerteis, Silke
      foaf_surname: Haerteis
  - foaf_Person:
      foaf_givenName: Matthias
      foaf_name: Zenkel, Matthias
      foaf_surname: Zenkel
  - foaf_Person:
      foaf_givenName: Verena E.
      foaf_name: Chankiewitz, Verena E.
      foaf_surname: Chankiewitz
  - foaf_Person:
      foaf_givenName: Kerstin U.
      foaf_name: Amann, Kerstin U.
      foaf_surname: Amann
  - foaf_Person:
      foaf_givenName: Friedrich E.
      foaf_name: Kruse, Friedrich E.
      foaf_surname: Kruse
  - foaf_Person:
      foaf_givenName: Christoph
      foaf_name: Korbmacher, Christoph
      foaf_surname: Korbmacher
  bibo_doi: 10.1167/iovs.11-8581
  bibo_issue: '2'
  bibo_volume: 53
  dct_date: 2012^xs_gYear
  dct_language: eng
  dct_publisher: Association for Research in Vision and Ophthalmology (ARVO)@
  dct_title: Four Subunits ($\alpha$$\beta$$\gamma$$\delta$) of the Epithelial Sodium
    Channel (ENaC) Are Expressed in the Human Eye in Various Locations@
...