---
res:
  bibo_abstract:
  - Over the last few decades, nanotechnology has established to be a promising field
    in medicine. A remaining dominant challenge in today's pharmacotherapy is the
    limited selectivity of active pharmaceutical ingredients and associated undesirable
    side effects. Controlled drug release can be promoted by smart drug delivery systems,
    which release embedded API primarily depending on specific stimuli. Consequently,
    also the microenvironment of tumor tissue can be used advantageously. Dithiothreitol
    (DTT) based self-immolative polydisulfides were synthesized that preferentially
    respond to pathologically increased glutathione (GSH) concentrations, as found
    in solid tumors. The synthesis with different degrees of polymerisation was investigated
    as well as the synthesis of a copolymer consisting of dithiothreitol and butanedithiol
    (BDT). Toxicity tests were carried out on pure polymers and their degradation
    products. The ability to degrade was examined at pathological and physiological
    glutathione concentrations in order to test the suitability of the polymer as
    a matrix for nanoparticulate carrier systems. In addition, the processability
    of one polymer into nanoparticles was investigated as well as the degradation
    behaviour with glutathione.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Katharina
      foaf_name: Völlmecke, Katharina
      foaf_surname: Völlmecke
  - foaf_Person:
      foaf_givenName: Maurice
      foaf_name: Kramer, Maurice
      foaf_surname: Kramer
  - foaf_Person:
      foaf_givenName: Corinna
      foaf_name: Horky, Corinna
      foaf_surname: Horky
  - foaf_Person:
      foaf_givenName: Oliver
      foaf_name: Dückmann, Oliver
      foaf_surname: Dückmann
  - foaf_Person:
      foaf_givenName: Dennis
      foaf_name: Mulac, Dennis
      foaf_surname: Mulac
  - foaf_Person:
      foaf_givenName: Klaus
      foaf_name: Langer, Klaus
      foaf_surname: Langer
  - foaf_Person:
      foaf_givenName: Dirk
      foaf_name: Kuckling, Dirk
      foaf_surname: Kuckling
      foaf_workInfoHomepage: http://www.librecat.org/personId=287
  bibo_doi: 10.1039/d4ra07228f
  bibo_issue: '48'
  bibo_volume: 14
  dct_date: 2024^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/2046-2069
  dct_language: eng
  dct_publisher: Royal Society of Chemistry (RSC)@
  dct_title: Self-immolative polydisulfides and their use as nanoparticles for drug
    delivery systems@
...