---
_id: '60044'
abstract:
- lang: eng
  text: <jats:title>Abstract</jats:title><jats:p>Exercise is described to provoke
    enhancements of cardiorespiratory fitness in persons with Multiple Sclerosis (pwMS).
    However, a high inter-individual variability in training responses has been observed.
    This analysis investigates response heterogeneity in cardiorespiratory fitness
    following high intensity interval (HIIT) and moderate continuous training (MCT)
    and analyzes potential predictors of cardiorespiratory training effects in pwMS.
    131 pwMS performed HIIT or MCT 3–5x/ week on a cycle ergometer for three weeks.
    Individual responses were classified. Finally, a multiple linear regression was
    conducted to examine potential associations between changes of absolute peak oxygen
    consumption (absolute ∆V̇O2peak/kg), training modality and participant’s characteristics.
    Results show a time and interaction effect for ∆V̇O2peak/kg. Absolute changes
    of cardiorespiratory responses were larger and the non-response proportions smaller
    in HIIT vs. MCT. The model accounting for 8.6% of the variance of ∆V̇O2peak/kg
    suggests that HIIT, younger age and lower baseline fitness predict a higher absolute
    ∆V̇O2peak/kg following an exercise intervention. Thus, this work implements a
    novel approach that investigates potential determinants of cardiorespiratory response
    heterogeneity within a clinical setting and analyzes a remarkable bigger sample.
    Further predictors need to be identified to increase the knowledge about response
    heterogeneity, thereby supporting the development of individualized training recommendations
    for pwMS.</jats:p>
author:
- first_name: Marit Lea
  full_name: Schlagheck, Marit Lea
  id: '117661'
  last_name: Schlagheck
  orcid: '0000-0002-8913-6080 '
- first_name: Anika
  full_name: Wucherer, Anika
  last_name: Wucherer
- first_name: Annette
  full_name: Rademacher, Annette
  last_name: Rademacher
- first_name: Niklas
  full_name: Joisten, Niklas
  last_name: Joisten
- first_name: Sebastian
  full_name: Proschinger, Sebastian
  last_name: Proschinger
- first_name: David
  full_name: Walzik, David
  last_name: Walzik
- first_name: Wilhelm
  full_name: Bloch, Wilhelm
  last_name: Bloch
- first_name: Jan
  full_name: Kool, Jan
  last_name: Kool
- first_name: Roman
  full_name: Gonzenbach, Roman
  last_name: Gonzenbach
- first_name: Jens
  full_name: Bansi, Jens
  last_name: Bansi
- first_name: Philipp
  full_name: Zimmer, Philipp
  last_name: Zimmer
citation:
  ama: 'Schlagheck ML, Wucherer A, Rademacher A, et al. VO2peak Response Heterogeneity
    in Persons with Multiple Sclerosis: To HIIT or Not to HIIT? <i>International Journal
    of Sports Medicine</i>. 2021;42(14):1319-1328. doi:<a href="https://doi.org/10.1055/a-1481-8639">10.1055/a-1481-8639</a>'
  apa: 'Schlagheck, M. L., Wucherer, A., Rademacher, A., Joisten, N., Proschinger,
    S., Walzik, D., Bloch, W., Kool, J., Gonzenbach, R., Bansi, J., &#38; Zimmer,
    P. (2021). VO2peak Response Heterogeneity in Persons with Multiple Sclerosis:
    To HIIT or Not to HIIT? <i>International Journal of Sports Medicine</i>, <i>42</i>(14),
    1319–1328. <a href="https://doi.org/10.1055/a-1481-8639">https://doi.org/10.1055/a-1481-8639</a>'
  bibtex: '@article{Schlagheck_Wucherer_Rademacher_Joisten_Proschinger_Walzik_Bloch_Kool_Gonzenbach_Bansi_et
    al._2021, title={VO2peak Response Heterogeneity in Persons with Multiple Sclerosis:
    To HIIT or Not to HIIT?}, volume={42}, DOI={<a href="https://doi.org/10.1055/a-1481-8639">10.1055/a-1481-8639</a>},
    number={14}, journal={International Journal of Sports Medicine}, publisher={Georg
    Thieme Verlag KG}, author={Schlagheck, Marit Lea and Wucherer, Anika and Rademacher,
    Annette and Joisten, Niklas and Proschinger, Sebastian and Walzik, David and Bloch,
    Wilhelm and Kool, Jan and Gonzenbach, Roman and Bansi, Jens and et al.}, year={2021},
    pages={1319–1328} }'
  chicago: 'Schlagheck, Marit Lea, Anika Wucherer, Annette Rademacher, Niklas Joisten,
    Sebastian Proschinger, David Walzik, Wilhelm Bloch, et al. “VO2peak Response Heterogeneity
    in Persons with Multiple Sclerosis: To HIIT or Not to HIIT?” <i>International
    Journal of Sports Medicine</i> 42, no. 14 (2021): 1319–28. <a href="https://doi.org/10.1055/a-1481-8639">https://doi.org/10.1055/a-1481-8639</a>.'
  ieee: 'M. L. Schlagheck <i>et al.</i>, “VO2peak Response Heterogeneity in Persons
    with Multiple Sclerosis: To HIIT or Not to HIIT?,” <i>International Journal of
    Sports Medicine</i>, vol. 42, no. 14, pp. 1319–1328, 2021, doi: <a href="https://doi.org/10.1055/a-1481-8639">10.1055/a-1481-8639</a>.'
  mla: 'Schlagheck, Marit Lea, et al. “VO2peak Response Heterogeneity in Persons with
    Multiple Sclerosis: To HIIT or Not to HIIT?” <i>International Journal of Sports
    Medicine</i>, vol. 42, no. 14, Georg Thieme Verlag KG, 2021, pp. 1319–28, doi:<a
    href="https://doi.org/10.1055/a-1481-8639">10.1055/a-1481-8639</a>.'
  short: M.L. Schlagheck, A. Wucherer, A. Rademacher, N. Joisten, S. Proschinger,
    D. Walzik, W. Bloch, J. Kool, R. Gonzenbach, J. Bansi, P. Zimmer, International
    Journal of Sports Medicine 42 (2021) 1319–1328.
date_created: 2025-05-27T07:54:18Z
date_updated: 2025-06-02T09:33:48Z
doi: 10.1055/a-1481-8639
extern: '1'
intvolume: '        42'
issue: '14'
language:
- iso: eng
page: 1319-1328
publication: International Journal of Sports Medicine
publication_identifier:
  issn:
  - 0172-4622
  - 1439-3964
publication_status: published
publisher: Georg Thieme Verlag KG
status: public
title: 'VO2peak Response Heterogeneity in Persons with Multiple Sclerosis: To HIIT
  or Not to HIIT?'
type: journal_article
user_id: '117661'
volume: 42
year: '2021'
...