{"department":[{"_id":"302"}],"author":[{"full_name":"Velpula, Gangamallaiah","last_name":"Velpula","first_name":"Gangamallaiah"},{"full_name":"Tomm, Emilia","last_name":"Tomm","first_name":"Emilia"},{"last_name":"Shen","full_name":"Shen, Boxuan","first_name":"Boxuan"},{"first_name":"Kunal S.","last_name":"Mali","full_name":"Mali, Kunal S."},{"id":"48864","first_name":"Adrian Clemens","last_name":"Keller","full_name":"Keller, Adrian Clemens","orcid":"0000-0001-7139-3110"},{"full_name":"De Feyter, Steven","last_name":"De Feyter","first_name":"Steven"}],"status":"public","abstract":[{"lang":"eng","text":"<jats:title>Abstract</jats:title><jats:p>Controlling the surface orientation of DNA origami nanostructures (DON) is crucial for applications in nanotechnology and materials science. While previous work utilized various DON modifications, simple methods for controlling their landing orientation remain scarce. Here, we demonstrate a straightforward approach to control the adsorption orientation of chiral double‐L (CDL) DON on mica by tuning magnesium ion (Mg<jats:sup>2</jats:sup>⁺) concentration and exploiting global shape distortions. Using atomic force microscopy (AFM), we analyzed the resulting distribution of the mirror‐image orientations, referred to as S and Z orientations, at both buffer/mica and air/mica interfaces and identified conditions resulting in homogenous CDL orientation of 100% S. These results demonstrate how DON conformation and ionic environments influence DON orientation, offering insights for precise nanostructure deposition.</jats:p>"}],"language":[{"iso":"eng"}],"doi":"10.1002/anie.202507613","publication_status":"published","date_created":"2025-10-13T13:53:22Z","date_updated":"2025-10-13T13:55:05Z","publication_identifier":{"issn":["1433-7851","1521-3773"]},"type":"journal_article","_id":"61821","citation":{"mla":"Velpula, Gangamallaiah, et al. “Breaking of the Up‐Down Symmetry of DNA Origami on a Solid Substrate.” <i>Angewandte Chemie International Edition</i>, e202507613, Wiley, 2025, doi:<a href=\"https://doi.org/10.1002/anie.202507613\">10.1002/anie.202507613</a>.","ieee":"G. Velpula, E. Tomm, B. Shen, K. S. Mali, A. C. Keller, and S. De Feyter, “Breaking of the Up‐Down Symmetry of DNA Origami on a Solid Substrate,” <i>Angewandte Chemie International Edition</i>, Art. no. e202507613, 2025, doi: <a href=\"https://doi.org/10.1002/anie.202507613\">10.1002/anie.202507613</a>.","bibtex":"@article{Velpula_Tomm_Shen_Mali_Keller_De Feyter_2025, title={Breaking of the Up‐Down Symmetry of DNA Origami on a Solid Substrate}, DOI={<a href=\"https://doi.org/10.1002/anie.202507613\">10.1002/anie.202507613</a>}, number={e202507613}, journal={Angewandte Chemie International Edition}, publisher={Wiley}, author={Velpula, Gangamallaiah and Tomm, Emilia and Shen, Boxuan and Mali, Kunal S. and Keller, Adrian Clemens and De Feyter, Steven}, year={2025} }","ama":"Velpula G, Tomm E, Shen B, Mali KS, Keller AC, De Feyter S. Breaking of the Up‐Down Symmetry of DNA Origami on a Solid Substrate. <i>Angewandte Chemie International Edition</i>. Published online 2025. doi:<a href=\"https://doi.org/10.1002/anie.202507613\">10.1002/anie.202507613</a>","short":"G. Velpula, E. Tomm, B. Shen, K.S. Mali, A.C. Keller, S. De Feyter, Angewandte Chemie International Edition (2025).","chicago":"Velpula, Gangamallaiah, Emilia Tomm, Boxuan Shen, Kunal S. Mali, Adrian Clemens Keller, and Steven De Feyter. “Breaking of the Up‐Down Symmetry of DNA Origami on a Solid Substrate.” <i>Angewandte Chemie International Edition</i>, 2025. <a href=\"https://doi.org/10.1002/anie.202507613\">https://doi.org/10.1002/anie.202507613</a>.","apa":"Velpula, G., Tomm, E., Shen, B., Mali, K. S., Keller, A. C., &#38; De Feyter, S. (2025). Breaking of the Up‐Down Symmetry of DNA Origami on a Solid Substrate. <i>Angewandte Chemie International Edition</i>, Article e202507613. <a href=\"https://doi.org/10.1002/anie.202507613\">https://doi.org/10.1002/anie.202507613</a>"},"title":"Breaking of the Up‐Down Symmetry of DNA Origami on a Solid Substrate","year":"2025","article_number":"e202507613","publisher":"Wiley","publication":"Angewandte Chemie International Edition","user_id":"48864"}