---
res:
  bibo_abstract:
  - <jats:title>Abstract</jats:title><jats:p>The biocatalytic kinetic resolution of
    cyclic carbonates derived from glycerol is reported. A selection of 26 esterases
    and lipases was tested for the asymmetric hydrolysis of the model substrate (epichlorohydrin
    carbonate) in aqueous medium. Among them, Pig Liver Esterase and Novozym® 435
    showed the best selectivity with <jats:italic>E</jats:italic>=38 and 49, respectively.
    Both enzymes were employed for the conversion of 12 glycerol derivatives under
    optimized conditions. The resolution of halogenated carbonates afforded the unconverted
    enantiomer in up to &gt;99 : 1 <jats:italic>er</jats:italic>. Furthermore, Novozym®
    435 was successfully recycled 10 times without significant loss of activity. Upscaling
    and isolation of the chiral carbonate was also demonstrated. Subsequent conversion
    of this chiral building block allowed the direct one‐pot synthesis of (<jats:italic>S</jats:italic>)‐Guaifenesin,
    (<jats:italic>S</jats:italic>)‐Mephenesin and (<jats:italic>S</jats:italic>)‐Chlorphenesin
    in up to 89 % yield and 94 : 6 <jats:italic>er</jats:italic>.</jats:p>@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Constanza
      foaf_name: Terazzi, Constanza
      foaf_surname: Terazzi
  - foaf_Person:
      foaf_givenName: Anke
      foaf_name: Spannenberg, Anke
      foaf_surname: Spannenberg
  - foaf_Person:
      foaf_givenName: Jan
      foaf_name: von Langermann, Jan
      foaf_surname: von Langermann
  - foaf_Person:
      foaf_givenName: Thomas
      foaf_name: Werner, Thomas
      foaf_surname: Werner
      foaf_workInfoHomepage: http://www.librecat.org/personId=89271
    orcid: 0000-0001-9025-3244
  bibo_doi: 10.1002/cctc.202300917
  bibo_issue: '19'
  bibo_volume: 15
  dct_date: 2023^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/1867-3880
  - http://id.crossref.org/issn/1867-3899
  dct_language: eng
  dct_publisher: Wiley@
  dct_subject:
  - T1
  - T4
  - CSSD
  dct_title: Chemoenzymatic Synthesis of Chiral Building Blocks Based on the Kinetic
    Resolution of Glycerol‐Derived Cyclic Carbonates@
...