---
res:
  bibo_abstract:
  - 'Spray-induced gene silencing (SIGS) employing double-stranded RNA (dsRNA) offers
    a promising, species-specific approach for protecting crops from insect pests
    such as the cabbage stem flea beetle (Psylliodes chrysocephala). However, the
    environmental instability of dsRNA presents a major limitation to its field application.
    In this study, we evaluate two distinct dsRNA formulation strategies for improved
    stability and delivery: a bottom-up approach using chitosan-based interpolyelectrolyte
    complexes (IPEC) and a top-down approach employing functionalized mesoporous silica
    carriers (SBA-15). Both systems were comprehensively characterized in terms of
    size, surface potential, porosity, and release behavior. The results revealed
    that IPECs exhibited release kinetics that were approximately one order of magnitude
    faster than those of SBA-15 across all tested conditions. The two formulations
    significantly improved dsRNA stability against UV and heat exposure compared to
    free dsRNA. In feeding assays with P. chrysocephala, both carriers achieved comparable
    gene silencing efficacy, though dsRNA@IPEC induced more immediate effects, while
    dsRNA@SBA-15 displayed delayed but ultimately stronger reduction in consumed leaf
    area, consistent with its slower release kinetics. We demonstrate that despite
    structural and mechanistic differences, both delivery platforms effectively stabilized
    and delivered dsRNA, and offered distinct advantages depending on application
    needs. This work highlights how formulation strategies are key to successful SIGS
    and supports the development of robust, field-adaptable formulation technologies
    for sustainable pest management.@eng'
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Benjamin W.
      foaf_name: Moorlach, Benjamin W.
      foaf_surname: Moorlach
  - foaf_Person:
      foaf_givenName: Robert
      foaf_name: Epkenhans, Robert
      foaf_surname: Epkenhans
  - foaf_Person:
      foaf_givenName: Di
      foaf_name: Ju, Di
      foaf_surname: Ju
  - foaf_Person:
      foaf_givenName: Banuja
      foaf_name: Ravidas, Banuja
      foaf_surname: Ravidas
  - foaf_Person:
      foaf_givenName: Christian
      foaf_name: Weinberger, Christian
      foaf_surname: Weinberger
      foaf_workInfoHomepage: http://www.librecat.org/personId=11848
  - foaf_Person:
      foaf_givenName: Michael
      foaf_name: Tiemann, Michael
      foaf_surname: Tiemann
      foaf_workInfoHomepage: http://www.librecat.org/personId=23547
    orcid: 0000-0003-1711-2722
  - foaf_Person:
      foaf_givenName: Judith
      foaf_name: Buente, Judith
      foaf_surname: Buente
  - foaf_Person:
      foaf_givenName: Maik
      foaf_name: Gaerner, Maik
      foaf_surname: Gaerner
  - foaf_Person:
      foaf_givenName: Martin
      foaf_name: Wortmann, Martin
      foaf_surname: Wortmann
  - foaf_Person:
      foaf_givenName: Stefan
      foaf_name: Scholten, Stefan
      foaf_surname: Scholten
  - foaf_Person:
      foaf_givenName: Michael
      foaf_name: Rostas, Michael
      foaf_surname: Rostas
  - foaf_Person:
      foaf_givenName: Waldemar
      foaf_name: Keil, Waldemar
      foaf_surname: Keil
  - foaf_Person:
      foaf_givenName: Anant V.
      foaf_name: Patel, Anant V.
      foaf_surname: Patel
  bibo_doi: 10.1016/j.ijbiomac.2025.149697
  bibo_volume: 338
  dct_date: 2026^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/0141-8130
  dct_language: eng
  dct_publisher: Elsevier BV@
  dct_title: DsRNA-based carriers with pH-tuneable release kinetics for effective
    control of Psylliodes chrysocephala@
...