---
_id: '65934'
abstract:
- lang: eng
  text: "<jats:sec>\r\n                    <jats:title>Introduction</jats:title>\r\n
    \                   <jats:p>Age-related changes in brain signal complexity are
    associated with cognitive decline and reduced neural adaptivity in older adults.
    Exergaming offers a promising prophylactic intervention combining physical and
    cognitive training. The aim of the present study was to assess how exergaming
    alters the temporal trajectory of brain signal complexity at rest and during gameplay
    in older adults.</jats:p>\r\n                  </jats:sec>\r\n                  <jats:sec>\r\n
    \                   <jats:title>Methods</jats:title>\r\n                    <jats:p>Twenty-eight
    healthy older adults participated in a 4-week exergaming intervention. Electroencephalography
    was recorded using 64 electrodes at rest (pre- and post-intervention) and during
    exergaming (pre-, mid-, and post-intervention). Brain signal complexity was quantified
    using multiscale entropy across 64 time scales on preprocessed signals.</jats:p>\r\n
    \                 </jats:sec>\r\n                  <jats:sec>\r\n                    <jats:title>Results</jats:title>\r\n
    \                   <jats:p>Post-intervention resting-state analysis revealed
    significant reductions at fine and increases at coarse scales in frontal, central,
    and posterior entropy. During gameplay, entropy declined widespread by mid-intervention,
    particularly at coarse scales over frontal, central and temporal regions. From
    mid- to post-intervention, the decline narrowed leaving a net pre-to-post reduction
    concentrated at coarse scales in these regions.</jats:p>\r\n                  </jats:sec>\r\n
    \                 <jats:sec>\r\n                    <jats:title>Discussion</jats:title>\r\n
    \                   <jats:p>Resting-state changes indicated a shift toward a younger
    brain profile, characterized by a transition from age-related increases in local
    processing to enhanced distributed processing, which may potentially mitigate
    the rise in neural modularity associated with aging. During gameplay, brain signal
    complexity decreased in week 2, followed by a modest change by week 4, consistent
    with the framework in which complexity initially streamlines and then adjusts
    toward a task-specific optimum. These findings suggest that exergaming can beneficially
    modulate brain complexity in older adults, offering the potential to reduce age-related
    neural decline and support healthy brain aging.</jats:p>\r\n                  </jats:sec>"
article_number: '1748274'
author:
- first_name: Daghan Yüksel
  full_name: Piskin, Daghan Yüksel
  id: '76790'
  last_name: Piskin
  orcid: 000-0002-3358-4669
- first_name: Helen Martha
  full_name: Müller, Helen Martha
  id: '40188'
  last_name: Müller
- first_name: Nina
  full_name: Skjæret-Maroni, Nina
  last_name: Skjæret-Maroni
- first_name: Beatrix
  full_name: Vereijken, Beatrix
  last_name: Vereijken
- first_name: Jochen
  full_name: Baumeister, Jochen
  id: '46'
  last_name: Baumeister
  orcid: 0000-0003-2683-5826
citation:
  ama: 'Piskin DY, Müller HM, Skjæret-Maroni N, Vereijken B, Baumeister J. Rewiring
    the aging brain: exergaming modulates brain complexity in older adults. <i>Frontiers
    in Aging Neuroscience</i>. 2026;17. doi:<a href="https://doi.org/10.3389/fnagi.2025.1748274">10.3389/fnagi.2025.1748274</a>'
  apa: 'Piskin, D. Y., Müller, H. M., Skjæret-Maroni, N., Vereijken, B., &#38; Baumeister,
    J. (2026). Rewiring the aging brain: exergaming modulates brain complexity in
    older adults. <i>Frontiers in Aging Neuroscience</i>, <i>17</i>, Article 1748274.
    <a href="https://doi.org/10.3389/fnagi.2025.1748274">https://doi.org/10.3389/fnagi.2025.1748274</a>'
  bibtex: '@article{Piskin_Müller_Skjæret-Maroni_Vereijken_Baumeister_2026, title={Rewiring
    the aging brain: exergaming modulates brain complexity in older adults}, volume={17},
    DOI={<a href="https://doi.org/10.3389/fnagi.2025.1748274">10.3389/fnagi.2025.1748274</a>},
    number={1748274}, journal={Frontiers in Aging Neuroscience}, publisher={Frontiers
    Media SA}, author={Piskin, Daghan Yüksel and Müller, Helen Martha and Skjæret-Maroni,
    Nina and Vereijken, Beatrix and Baumeister, Jochen}, year={2026} }'
  chicago: 'Piskin, Daghan Yüksel, Helen Martha Müller, Nina Skjæret-Maroni, Beatrix
    Vereijken, and Jochen Baumeister. “Rewiring the Aging Brain: Exergaming Modulates
    Brain Complexity in Older Adults.” <i>Frontiers in Aging Neuroscience</i> 17 (2026).
    <a href="https://doi.org/10.3389/fnagi.2025.1748274">https://doi.org/10.3389/fnagi.2025.1748274</a>.'
  ieee: 'D. Y. Piskin, H. M. Müller, N. Skjæret-Maroni, B. Vereijken, and J. Baumeister,
    “Rewiring the aging brain: exergaming modulates brain complexity in older adults,”
    <i>Frontiers in Aging Neuroscience</i>, vol. 17, Art. no. 1748274, 2026, doi:
    <a href="https://doi.org/10.3389/fnagi.2025.1748274">10.3389/fnagi.2025.1748274</a>.'
  mla: 'Piskin, Daghan Yüksel, et al. “Rewiring the Aging Brain: Exergaming Modulates
    Brain Complexity in Older Adults.” <i>Frontiers in Aging Neuroscience</i>, vol.
    17, 1748274, Frontiers Media SA, 2026, doi:<a href="https://doi.org/10.3389/fnagi.2025.1748274">10.3389/fnagi.2025.1748274</a>.'
  short: D.Y. Piskin, H.M. Müller, N. Skjæret-Maroni, B. Vereijken, J. Baumeister,
    Frontiers in Aging Neuroscience 17 (2026).
date_created: 2026-06-18T11:31:27Z
date_updated: 2026-06-18T11:31:59Z
department:
- _id: '172'
doi: 10.3389/fnagi.2025.1748274
intvolume: '        17'
language:
- iso: eng
publication: Frontiers in Aging Neuroscience
publication_identifier:
  issn:
  - 1663-4365
publication_status: published
publisher: Frontiers Media SA
status: public
title: 'Rewiring the aging brain: exergaming modulates brain complexity in older adults'
type: journal_article
user_id: '76790'
volume: 17
year: '2026'
...