---
res:
  bibo_abstract:
  - "<jats:p>\r\n                    DNA origami nanostructures (DONs) have promising
    applications in biomedicine and biosensing, which often require their efficient
    binding to target cells. By immobilizing the glycopeptide antibiotic vancomycin
    on DONs, DON binding to Gram‐positive and Gram‐negative bacteria can be facilitated.
    Here, we investigate how this multivalent binding is affected by the number and
    arrangement of the vancomycin modifications on two‐dimensional DONs. We find that
    for both Gram‐positive\r\n                    <jats:italic>Bacillus subtilis</jats:italic>\r\n
    \                   and Gram‐negative\r\n                    <jats:italic>Escherichia
    coli</jats:italic>\r\n                    , binding increases with the number
    of vancomycin modifications per DON. In general, binding to\r\n                    <jats:italic>E.
    coli</jats:italic>\r\n                    is stronger than to\r\n                    <jats:italic>B.
    subtilis</jats:italic>\r\n                    , which may be attributed to differences
    in the architectures of the cell envelopes. Interestingly, for both bacteria,
    the total number of vancomycin modifications appears to be more important than
    their arrangement, as DONs with 18 vancomycin molecules on one side show similar
    binding as DONs with 18 vancomycin molecules distributed over both sides. This
    enables the attachment of multiple probe molecules to the vancomycin‐free side
    of the DONs for enhancing detection efficiency without compromising binding affinity.
    These results may thus provide guidelines for the design and synthesis of vancomycin‐modified
    DONs for antimicrobial drug delivery and pathogen detection.\r\n                  </jats:p>@eng"
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Özge
      foaf_name: Coşkuner Leineweber, Özge
      foaf_surname: Coşkuner Leineweber
  - foaf_Person:
      foaf_givenName: Ulrike
      foaf_name: Hofmann, Ulrike
      foaf_surname: Hofmann
  - foaf_Person:
      foaf_givenName: Guido
      foaf_name: Grundmeier, Guido
      foaf_surname: Grundmeier
      foaf_workInfoHomepage: http://www.librecat.org/personId=194
  - foaf_Person:
      foaf_givenName: Yixin
      foaf_name: Zhang, Yixin
      foaf_surname: Zhang
  - foaf_Person:
      foaf_givenName: Adrian Clemens
      foaf_name: Keller, Adrian Clemens
      foaf_surname: Keller
      foaf_workInfoHomepage: http://www.librecat.org/personId=48864
    orcid: 0000-0001-7139-3110
  bibo_doi: 10.1002/cbic.70436
  bibo_issue: '13'
  bibo_volume: 27
  dct_date: 2026^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/1439-4227
  - http://id.crossref.org/issn/1439-7633
  dct_language: eng
  dct_publisher: Wiley@
  dct_title: Vancomycin‐Mediated Binding of DNA Origami Nanostructures to Gram‐Positive
    and Gram‐Negative Bacteria@
...