---
_id: '66092'
abstract:
- lang: eng
  text: "<jats:p>\r\n                    DNA origami nanostructures (DONs) have promising
    applications in biomedicine and biosensing, which often require their efficient
    binding to target cells. By immobilizing the glycopeptide antibiotic vancomycin
    on DONs, DON binding to Gram‐positive and Gram‐negative bacteria can be facilitated.
    Here, we investigate how this multivalent binding is affected by the number and
    arrangement of the vancomycin modifications on two‐dimensional DONs. We find that
    for both Gram‐positive\r\n                    <jats:italic>Bacillus subtilis</jats:italic>\r\n
    \                   and Gram‐negative\r\n                    <jats:italic>Escherichia
    coli</jats:italic>\r\n                    , binding increases with the number
    of vancomycin modifications per DON. In general, binding to\r\n                    <jats:italic>E.
    coli</jats:italic>\r\n                    is stronger than to\r\n                    <jats:italic>B.
    subtilis</jats:italic>\r\n                    , which may be attributed to differences
    in the architectures of the cell envelopes. Interestingly, for both bacteria,
    the total number of vancomycin modifications appears to be more important than
    their arrangement, as DONs with 18 vancomycin molecules on one side show similar
    binding as DONs with 18 vancomycin molecules distributed over both sides. This
    enables the attachment of multiple probe molecules to the vancomycin‐free side
    of the DONs for enhancing detection efficiency without compromising binding affinity.
    These results may thus provide guidelines for the design and synthesis of vancomycin‐modified
    DONs for antimicrobial drug delivery and pathogen detection.\r\n                  </jats:p>"
article_number: e70436
author:
- first_name: Özge
  full_name: Coşkuner Leineweber, Özge
  last_name: Coşkuner Leineweber
- first_name: Ulrike
  full_name: Hofmann, Ulrike
  last_name: Hofmann
- first_name: Guido
  full_name: Grundmeier, Guido
  id: '194'
  last_name: Grundmeier
- first_name: Yixin
  full_name: Zhang, Yixin
  last_name: Zhang
- first_name: Adrian Clemens
  full_name: Keller, Adrian Clemens
  id: '48864'
  last_name: Keller
  orcid: 0000-0001-7139-3110
citation:
  ama: Coşkuner Leineweber Ö, Hofmann U, Grundmeier G, Zhang Y, Keller AC. Vancomycin‐Mediated
    Binding of DNA Origami Nanostructures to Gram‐Positive and Gram‐Negative Bacteria.
    <i>ChemBioChem</i>. 2026;27(13). doi:<a href="https://doi.org/10.1002/cbic.70436">10.1002/cbic.70436</a>
  apa: Coşkuner Leineweber, Ö., Hofmann, U., Grundmeier, G., Zhang, Y., &#38; Keller,
    A. C. (2026). Vancomycin‐Mediated Binding of DNA Origami Nanostructures to Gram‐Positive
    and Gram‐Negative Bacteria. <i>ChemBioChem</i>, <i>27</i>(13), Article e70436.
    <a href="https://doi.org/10.1002/cbic.70436">https://doi.org/10.1002/cbic.70436</a>
  bibtex: '@article{Coşkuner Leineweber_Hofmann_Grundmeier_Zhang_Keller_2026, title={Vancomycin‐Mediated
    Binding of DNA Origami Nanostructures to Gram‐Positive and Gram‐Negative Bacteria},
    volume={27}, DOI={<a href="https://doi.org/10.1002/cbic.70436">10.1002/cbic.70436</a>},
    number={13e70436}, journal={ChemBioChem}, publisher={Wiley}, author={Coşkuner
    Leineweber, Özge and Hofmann, Ulrike and Grundmeier, Guido and Zhang, Yixin and
    Keller, Adrian Clemens}, year={2026} }'
  chicago: Coşkuner Leineweber, Özge, Ulrike Hofmann, Guido Grundmeier, Yixin Zhang,
    and Adrian Clemens Keller. “Vancomycin‐Mediated Binding of DNA Origami Nanostructures
    to Gram‐Positive and Gram‐Negative Bacteria.” <i>ChemBioChem</i> 27, no. 13 (2026).
    <a href="https://doi.org/10.1002/cbic.70436">https://doi.org/10.1002/cbic.70436</a>.
  ieee: 'Ö. Coşkuner Leineweber, U. Hofmann, G. Grundmeier, Y. Zhang, and A. C. Keller,
    “Vancomycin‐Mediated Binding of DNA Origami Nanostructures to Gram‐Positive and
    Gram‐Negative Bacteria,” <i>ChemBioChem</i>, vol. 27, no. 13, Art. no. e70436,
    2026, doi: <a href="https://doi.org/10.1002/cbic.70436">10.1002/cbic.70436</a>.'
  mla: Coşkuner Leineweber, Özge, et al. “Vancomycin‐Mediated Binding of DNA Origami
    Nanostructures to Gram‐Positive and Gram‐Negative Bacteria.” <i>ChemBioChem</i>,
    vol. 27, no. 13, e70436, Wiley, 2026, doi:<a href="https://doi.org/10.1002/cbic.70436">10.1002/cbic.70436</a>.
  short: Ö. Coşkuner Leineweber, U. Hofmann, G. Grundmeier, Y. Zhang, A.C. Keller,
    ChemBioChem 27 (2026).
date_created: 2026-06-30T12:44:05Z
date_updated: 2026-06-30T13:01:42Z
department:
- _id: '302'
doi: 10.1002/cbic.70436
intvolume: '        27'
issue: '13'
language:
- iso: eng
publication: ChemBioChem
publication_identifier:
  issn:
  - 1439-4227
  - 1439-7633
publication_status: published
publisher: Wiley
status: public
title: Vancomycin‐Mediated Binding of DNA Origami Nanostructures to Gram‐Positive
  and Gram‐Negative Bacteria
type: journal_article
user_id: '48864'
volume: 27
year: '2026'
...