---
_id: '66668'
abstract:
- lang: eng
  text: Over the last few decades, a large variety of nucleic acid‑based therapeutic
    approaches and drug formulations have been developed in the lab, tested in the
    clinic, and brought to market, ranging from antisense oligonucleotides (ASOs)
    and siRNAs to aptamer inhibitors and mRNA vaccines, with DNA and RNA nanostructure
    therapeutics already looming on the horizon. However, being susceptible toward
    hydrolysis, oxidation, non‑specific binding, and nuclease digestion, unmodified
    nucleic acids are rapidly degraded in vivo, resulting in poor therapeutic performance.
    Therefore, several stabilization strategies have been developed in order to protect
    those fragile molecules against adverse conditions during storage and in the body,
    while simultaneously accommodating their various mechanisms of action such as
    cellular uptake, target binding, or translation. These strategies include chemical
    modifications at the nucleoside level, complexation with proteins and polymers,
    and encapsulation in lipid nanoparticles (LNPs). Despite this variety of available
    methods, the field still faces many challenges, and this issue aims to provide
    an overview of the ongoing efforts to enhance the stability of therapeutic nucleic
    acids.
author:
- first_name: Adrian Clemens
  full_name: Keller, Adrian Clemens
  id: '48864'
  last_name: Keller
  orcid: 0000-0001-7139-3110
citation:
  ama: Keller AC. Ongoing efforts to enhance stability. <i>Nucleic Acid Insights</i>.
    2026;3(6):461–463. doi:<a href="https://doi.org/10.18609/nai.2026.055">10.18609/nai.2026.055</a>
  apa: Keller, A. C. (2026). Ongoing efforts to enhance stability. <i>Nucleic Acid
    Insights</i>, <i>3</i>(6), 461–463. <a href="https://doi.org/10.18609/nai.2026.055">https://doi.org/10.18609/nai.2026.055</a>
  bibtex: '@article{Keller_2026, title={Ongoing efforts to enhance stability}, volume={3},
    DOI={<a href="https://doi.org/10.18609/nai.2026.055">10.18609/nai.2026.055</a>},
    number={6}, journal={Nucleic Acid Insights}, author={Keller, Adrian Clemens},
    year={2026}, pages={461–463} }'
  chicago: 'Keller, Adrian Clemens. “Ongoing Efforts to Enhance Stability.” <i>Nucleic
    Acid Insights</i> 3, no. 6 (2026): 461–463. <a href="https://doi.org/10.18609/nai.2026.055">https://doi.org/10.18609/nai.2026.055</a>.'
  ieee: 'A. C. Keller, “Ongoing efforts to enhance stability,” <i>Nucleic Acid Insights</i>,
    vol. 3, no. 6, pp. 461–463, 2026, doi: <a href="https://doi.org/10.18609/nai.2026.055">10.18609/nai.2026.055</a>.'
  mla: Keller, Adrian Clemens. “Ongoing Efforts to Enhance Stability.” <i>Nucleic
    Acid Insights</i>, vol. 3, no. 6, 2026, pp. 461–463, doi:<a href="https://doi.org/10.18609/nai.2026.055">10.18609/nai.2026.055</a>.
  short: A.C. Keller, Nucleic Acid Insights 3 (2026) 461–463.
date_created: 2026-08-06T06:56:02Z
date_updated: 2026-08-06T06:59:39Z
ddc:
- '572'
department:
- _id: '302'
doi: 10.18609/nai.2026.055
file:
- access_level: open_access
  content_type: application/pdf
  creator: adke
  date_created: 2026-08-06T06:55:55Z
  date_updated: 2026-08-06T06:55:55Z
  file_id: '66669'
  file_name: Keller_nai26.pdf
  file_size: 278638
  relation: main_file
file_date_updated: 2026-08-06T06:55:55Z
has_accepted_license: '1'
intvolume: '         3'
issue: '6'
language:
- iso: eng
oa: '1'
page: 461–463
publication: Nucleic Acid Insights
status: public
title: Ongoing efforts to enhance stability
type: journal_article
user_id: '48864'
volume: 3
year: '2026'
...