---
res:
  bibo_abstract:
  - "<jats:title>Abstract</jats:title>\r\n                  <jats:p>\r\n                    Serum
    neurofilament light chain (sNfL) and glial fibrillary acidic protein (GFAP) are
    biomarkers of neuroaxonal and astrocytic damage but remain understudied in adolescent
    psychiatric populations. This study investigated sNfL and GFAP levels in 412 adolescents
    diagnosed with anorexia nervosa (AN) (\r\n                    <jats:italic>n</jats:italic>\r\n
    \                    = 52), depression (\r\n                    <jats:italic>n</jats:italic>\r\n
    \                    = 237), and other psychiatric disorders (\r\n                    <jats:italic>n</jats:italic>\r\n
    \                    = 123). We assessed their diagnostic utility, correlation
    with disease severity, and longitudinal changes during AN treatment. Biomarkers
    were measured using Single Molecule Array technology, with Z-scores derived from
    reference datasets. Compared to population norms, both biomarkers were elevated
    in AN (sNfL: 1.15 ± 1.17; GFAP: 1.50 ± 0.84) and in depression (sNfL: 0.34 ± 1.10;
    GFAP: 0.58 ± 1.00). Patients with AN showed significantly higher biomarker levels
    than those with depression or other psychiatric disorders; importantly, this distinction
    remained evident in sensitivity analyses restricted to underweight individuals
    with depression. In AN, sNfL levels correlated with baseline weight loss (β = −0.45,
    R² = 0.20) and declined significantly during treatment, while GFAP changes were
    less pronounced. Neither marker correlated with depressive symptom severity. Bootstrapped
    ROC analyses showed moderate-to-good discriminatory power (AUCs 0.70–0.84) for
    distinguishing AN from depression. These findings suggest that neuroaxonal and
    astrocytic stress is a component of adolescent psychopathology, particularly in
    AN. sNfL appears sensitive to starvation-related neurobiological changes, with
    levels normalizing alongside weight restoration. GFAP showed similar but less
    robust trends. Accordingly, the observed biomarker changes reflect more than underweight
    alone, supporting a potential role in differential diagnosis and treatment monitoring.\r\n
    \                 </jats:p>@eng"
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Marc
      foaf_name: Pawlitzki, Marc
      foaf_surname: Pawlitzki
  - foaf_Person:
      foaf_givenName: Lars
      foaf_name: Masanneck, Lars
      foaf_surname: Masanneck
  - foaf_Person:
      foaf_givenName: Laura
      foaf_name: Schlarbaum, Laura
      foaf_surname: Schlarbaum
      foaf_workInfoHomepage: http://www.librecat.org/personId=96697
  - foaf_Person:
      foaf_givenName: Nicole
      foaf_name: Jankovic, Nicole
      foaf_surname: Jankovic
  - foaf_Person:
      foaf_givenName: Stefan
      foaf_name: Bittner, Stefan
      foaf_surname: Bittner
  - foaf_Person:
      foaf_givenName: Falk
      foaf_name: Steffen, Falk
      foaf_surname: Steffen
  - foaf_Person:
      foaf_givenName: Jens
      foaf_name: Kuhle, Jens
      foaf_surname: Kuhle
  - foaf_Person:
      foaf_givenName: Pascal
      foaf_name: Benkert, Pascal
      foaf_surname: Benkert
  - foaf_Person:
      foaf_givenName: Jonathan
      foaf_name: Repple, Jonathan
      foaf_surname: Repple
  - foaf_Person:
      foaf_givenName: Judith
      foaf_name: Bühlmeier, Judith
      foaf_surname: Bühlmeier
  - foaf_Person:
      foaf_givenName: Anke
      foaf_name: Hinney, Anke
      foaf_surname: Hinney
  - foaf_Person:
      foaf_givenName: Johannes
      foaf_name: Hebebrand, Johannes
      foaf_surname: Hebebrand
  - foaf_Person:
      foaf_givenName: Raphael
      foaf_name: Hirtz, Raphael
      foaf_surname: Hirtz
  - foaf_Person:
      foaf_givenName: Sven
      foaf_name: G. Meuth, Sven
      foaf_surname: G. Meuth
  - foaf_Person:
      foaf_givenName: Lars
      foaf_name: Libuda, Lars
      foaf_surname: Libuda
      foaf_workInfoHomepage: http://www.librecat.org/personId=88682
    orcid: 0000-0003-1603-3133
  - foaf_Person:
      foaf_givenName: Manuel
      foaf_name: Föcker, Manuel
      foaf_surname: Föcker
  bibo_doi: 10.1038/s41398-026-04347-1
  bibo_issue: '1'
  bibo_volume: 16
  dct_date: 2026^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/2158-3188
  dct_language: eng
  dct_publisher: Springer Science and Business Media LLC@
  dct_title: 'Exploring serum biomarkers in paediatric psychiatry: the impact of NfL
    and GFAP@'
...