Evaluation of Metabolic Profiles of Patients with Anorexia Nervosa at Inpatient Admission, Short- and Long-Term Weight Regain—Descriptive and Pattern Analysis
M. Föcker, A. Cecil, C. Prehn, J. Adamski, M. Albrecht, F. Adams, A. Hinney, L. Libuda, J. Bühlmeier, J. Hebebrand, T. Peters, J. Antel, Metabolites (2020).
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Journal Article
| Published
| English
Author
Föcker, Manuel;
Cecil, Alexander;
Prehn, Cornelia;
Adamski, Jerzy;
Albrecht, Muriel;
Adams, Frederike;
Hinney, Anke;
Libuda, LarsLibreCat 
;
Bühlmeier, JudithLibreCat;
Hebebrand, Johannes;
Peters, Triinu;
Antel, Jochen
All
;
Bühlmeier, JudithLibreCat;
Hebebrand, Johannes;
Peters, Triinu;
Antel, Jochen
All
Department
Abstract
<jats:p>Acute anorexia nervosa (AN) constitutes an extreme physiological state. We aimed to detect state related metabolic alterations during inpatient admission and upon short- and long-term weight regain. In addition, we tested the hypothesis that metabolite concentrations adapt to those of healthy controls (HC) after long-term weight regain. Thirty-five female adolescents with AN and 25 female HC were recruited. Based on a targeted approach 187 metabolite concentrations were detected at inpatient admission (T0), after short-term weight recovery (T1; half of target-weight) and close to target weight (T2). Pattern hunter and time course analysis were performed. The highest number of significant differences in metabolite concentrations (N = 32) were observed between HC and T1. According to the detected main pattern, metabolite concentrations at T2 became more similar to those of HC. The course of single metabolite concentrations (e.g., glutamic acid) revealed different metabolic subtypes within the study sample. Patients with AN after short-term weight regain are in a greater “metabolic imbalance” than at starvation. After long-term weight regain, patients reach a metabolite profile similar to HC. Our results might be confounded by different metabolic subtypes of patients with AN.</jats:p>
Publishing Year
Journal Title
Metabolites
Article Number
7
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LibreCat-ID
Cite this
Föcker M, Cecil A, Prehn C, et al. Evaluation of Metabolic Profiles of Patients with Anorexia Nervosa at Inpatient Admission, Short- and Long-Term Weight Regain—Descriptive and Pattern Analysis. Metabolites. Published online 2020. doi:10.3390/metabo11010007
Föcker, M., Cecil, A., Prehn, C., Adamski, J., Albrecht, M., Adams, F., Hinney, A., Libuda, L., Bühlmeier, J., Hebebrand, J., Peters, T., & Antel, J. (2020). Evaluation of Metabolic Profiles of Patients with Anorexia Nervosa at Inpatient Admission, Short- and Long-Term Weight Regain—Descriptive and Pattern Analysis. Metabolites, Article 7. https://doi.org/10.3390/metabo11010007
@article{Föcker_Cecil_Prehn_Adamski_Albrecht_Adams_Hinney_Libuda_Bühlmeier_Hebebrand_et al._2020, title={Evaluation of Metabolic Profiles of Patients with Anorexia Nervosa at Inpatient Admission, Short- and Long-Term Weight Regain—Descriptive and Pattern Analysis}, DOI={10.3390/metabo11010007}, number={7}, journal={Metabolites}, author={Föcker, Manuel and Cecil, Alexander and Prehn, Cornelia and Adamski, Jerzy and Albrecht, Muriel and Adams, Frederike and Hinney, Anke and Libuda, Lars and Bühlmeier, Judith and Hebebrand, Johannes and et al.}, year={2020} }
Föcker, Manuel, Alexander Cecil, Cornelia Prehn, Jerzy Adamski, Muriel Albrecht, Frederike Adams, Anke Hinney, et al. “Evaluation of Metabolic Profiles of Patients with Anorexia Nervosa at Inpatient Admission, Short- and Long-Term Weight Regain—Descriptive and Pattern Analysis.” Metabolites, 2020. https://doi.org/10.3390/metabo11010007.
M. Föcker et al., “Evaluation of Metabolic Profiles of Patients with Anorexia Nervosa at Inpatient Admission, Short- and Long-Term Weight Regain—Descriptive and Pattern Analysis,” Metabolites, Art. no. 7, 2020, doi: 10.3390/metabo11010007.
Föcker, Manuel, et al. “Evaluation of Metabolic Profiles of Patients with Anorexia Nervosa at Inpatient Admission, Short- and Long-Term Weight Regain—Descriptive and Pattern Analysis.” Metabolites, 7, 2020, doi:10.3390/metabo11010007.
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