Short-term metreleptin treatment of patients with anorexia nervosa: rapid on-set of beneficial cognitive, emotional, and behavioral effects
G. Milos, J. Antel, L.-K. Kaufmann, N. Barth, A. Koller, S. Tan, U. Wiesing, A. Hinney, L. Libuda, M. Wabitsch, R. von Känel, J. Hebebrand, Translational Psychiatry (2020).
Download
No fulltext has been uploaded.
Journal Article
| Published
| English
Author
Milos, Gabriella;
Antel, Jochen;
Kaufmann, Lisa-Katrin;
Barth, Nikolaus;
Koller, Antonia;
Tan, Susanne;
Wiesing, Urban;
Hinney, Anke;
Libuda, LarsLibreCat 
;
Wabitsch, Martin;
von Känel, Roland;
Hebebrand, Johannes
All
;
Wabitsch, Martin;
von Känel, Roland;
Hebebrand, Johannes
All
Department
Abstract
<jats:title>Abstract</jats:title><jats:p>To examine the hypothesis that normalization of low circulating leptin levels in patients with anorexia nervosa ameliorates hyperactivity, three seriously ill females with hyperactivity were treated off-label with metreleptin (recombinant human leptin) for up to 14 days. Drive for activity, repetitive thoughts of food, inner restlessness, and weight phobia decreased in two patients. Surprisingly, depression improved rapidly in all patients. No serious adverse events occurred. Due to obvious limitations of uncontrolled case series, placebo-controlled clinical trials are mandatory to confirm the observed rapid onset of beneficial effects. Our findings suggest an important role of hypoleptinemia in the mental and behavioral phenotype of anorexia nervosa.</jats:p>
Publishing Year
Journal Title
Translational Psychiatry
ISSN
LibreCat-ID
Cite this
Milos G, Antel J, Kaufmann L-K, et al. Short-term metreleptin treatment of patients with anorexia nervosa: rapid on-set of beneficial cognitive, emotional, and behavioral effects. Translational Psychiatry. Published online 2020. doi:10.1038/s41398-020-00977-1
Milos, G., Antel, J., Kaufmann, L.-K., Barth, N., Koller, A., Tan, S., Wiesing, U., Hinney, A., Libuda, L., Wabitsch, M., von Känel, R., & Hebebrand, J. (2020). Short-term metreleptin treatment of patients with anorexia nervosa: rapid on-set of beneficial cognitive, emotional, and behavioral effects. Translational Psychiatry. https://doi.org/10.1038/s41398-020-00977-1
@article{Milos_Antel_Kaufmann_Barth_Koller_Tan_Wiesing_Hinney_Libuda_Wabitsch_et al._2020, title={Short-term metreleptin treatment of patients with anorexia nervosa: rapid on-set of beneficial cognitive, emotional, and behavioral effects}, DOI={10.1038/s41398-020-00977-1}, journal={Translational Psychiatry}, author={Milos, Gabriella and Antel, Jochen and Kaufmann, Lisa-Katrin and Barth, Nikolaus and Koller, Antonia and Tan, Susanne and Wiesing, Urban and Hinney, Anke and Libuda, Lars and Wabitsch, Martin and et al.}, year={2020} }
Milos, Gabriella, Jochen Antel, Lisa-Katrin Kaufmann, Nikolaus Barth, Antonia Koller, Susanne Tan, Urban Wiesing, et al. “Short-Term Metreleptin Treatment of Patients with Anorexia Nervosa: Rapid on-Set of Beneficial Cognitive, Emotional, and Behavioral Effects.” Translational Psychiatry, 2020. https://doi.org/10.1038/s41398-020-00977-1.
G. Milos et al., “Short-term metreleptin treatment of patients with anorexia nervosa: rapid on-set of beneficial cognitive, emotional, and behavioral effects,” Translational Psychiatry, 2020, doi: 10.1038/s41398-020-00977-1.
Milos, Gabriella, et al. “Short-Term Metreleptin Treatment of Patients with Anorexia Nervosa: Rapid on-Set of Beneficial Cognitive, Emotional, and Behavioral Effects.” Translational Psychiatry, 2020, doi:10.1038/s41398-020-00977-1.
Google Scholar