Vitamin D Level Trajectories of Adolescent Patients with Anorexia Nervosa at Inpatient Admission, during Treatment, and at One Year Follow Up: Association with Depressive Symptoms
M. Föcker, N. Timmesfeld, J. Bühlmeier, D. Zwanziger, D. Führer, C. Grasemann, S. Ehrlich, K. Egberts, C. Fleischhaker, C. Wewetzer, I. Wessing, J. Seitz, B. Herpertz-Dahlmann, J. Hebebrand, L. Libuda, Nutrients (2021).
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Author
Föcker, Manuel;
Timmesfeld, Nina;
Bühlmeier, JudithLibreCat;
Zwanziger, Denise;
Führer, Dagmar;
Grasemann, Corinna;
Ehrlich, Stefan;
Egberts, Karin;
Fleischhaker, Christian;
Wewetzer, Christoph;
Wessing, Ida;
Seitz, Jochen
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All
Department
Abstract
<jats:p>(1) Background: Evidence has accumulated that patients with anorexia nervosa (AN) are at higher risk for vitamin D deficiency than healthy controls. In epidemiologic studies, low 25(OH) vitamin D (25(OH)D) levels were associated with depression. This study analyzed the relationship between 25(OH)D serum levels in adolescent patients and AN and depressive symptoms over the course of treatment. (2) Methods: 25(OH)D levels and depressive symptoms were analyzed in 93 adolescent (in-)patients with AN from the Anorexia Nervosa Day patient versus Inpatient (ANDI) multicenter trial at clinic admission, discharge, and 1 year follow up. Mixed regression models were used to analyze the relationship between 25(OH)D levels and depressive symptoms assessed by the Beck Depression Inventory (BDI-II). (3) Results: Although mean 25(OH)D levels constantly remained in recommended ranges (≥50 nmol/L) during AN treatment, levels decreased from (in)patient admission to 1 year follow up. Levels of 25(OH)D were neither cross-sectionally, prospectively, nor longitudinally associated with the BDI-II score. (4) Conclusions: This study did not confirm that 25(OH)D levels are associated with depressive symptoms in patients with AN. However, increasing risks of vitamin D deficiency over the course of AN treatment indicate that clinicians should monitor 25(OH)D levels.</jats:p>
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Journal Title
Nutrients
Article Number
2356
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LibreCat-ID
Cite this
Föcker M, Timmesfeld N, Bühlmeier J, et al. Vitamin D Level Trajectories of Adolescent Patients with Anorexia Nervosa at Inpatient Admission, during Treatment, and at One Year Follow Up: Association with Depressive Symptoms. Nutrients. Published online 2021. doi:10.3390/nu13072356
Föcker, M., Timmesfeld, N., Bühlmeier, J., Zwanziger, D., Führer, D., Grasemann, C., Ehrlich, S., Egberts, K., Fleischhaker, C., Wewetzer, C., Wessing, I., Seitz, J., Herpertz-Dahlmann, B., Hebebrand, J., & Libuda, L. (2021). Vitamin D Level Trajectories of Adolescent Patients with Anorexia Nervosa at Inpatient Admission, during Treatment, and at One Year Follow Up: Association with Depressive Symptoms. Nutrients, Article 2356. https://doi.org/10.3390/nu13072356
@article{Föcker_Timmesfeld_Bühlmeier_Zwanziger_Führer_Grasemann_Ehrlich_Egberts_Fleischhaker_Wewetzer_et al._2021, title={Vitamin D Level Trajectories of Adolescent Patients with Anorexia Nervosa at Inpatient Admission, during Treatment, and at One Year Follow Up: Association with Depressive Symptoms}, DOI={10.3390/nu13072356}, number={2356}, journal={Nutrients}, author={Föcker, Manuel and Timmesfeld, Nina and Bühlmeier, Judith and Zwanziger, Denise and Führer, Dagmar and Grasemann, Corinna and Ehrlich, Stefan and Egberts, Karin and Fleischhaker, Christian and Wewetzer, Christoph and et al.}, year={2021} }
Föcker, Manuel, Nina Timmesfeld, Judith Bühlmeier, Denise Zwanziger, Dagmar Führer, Corinna Grasemann, Stefan Ehrlich, et al. “Vitamin D Level Trajectories of Adolescent Patients with Anorexia Nervosa at Inpatient Admission, during Treatment, and at One Year Follow Up: Association with Depressive Symptoms.” Nutrients, 2021. https://doi.org/10.3390/nu13072356.
M. Föcker et al., “Vitamin D Level Trajectories of Adolescent Patients with Anorexia Nervosa at Inpatient Admission, during Treatment, and at One Year Follow Up: Association with Depressive Symptoms,” Nutrients, Art. no. 2356, 2021, doi: 10.3390/nu13072356.
Föcker, Manuel, et al. “Vitamin D Level Trajectories of Adolescent Patients with Anorexia Nervosa at Inpatient Admission, during Treatment, and at One Year Follow Up: Association with Depressive Symptoms.” Nutrients, 2356, 2021, doi:10.3390/nu13072356.
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