Protein intake and cancer: an umbrella review of systematic reviews for the evidence-based guideline of the German Nutrition Society

T. Kühn, N. Kalotai, A.M. Amini, J. Haardt, A. Lehmann, A. Schmidt, A. Buyken, S. Egert, S. Ellinger, A. Kroke, S. Lorkowski, S. Louis, M.B. Schulze, L. Schwingshackl, R. Siener, G.I. Stangl, B. Watzl, A. Zittermann, K. Nimptsch, European Journal of Nutrition (2024).

Download
No fulltext has been uploaded.
Journal Article | Published | English
Author
Kühn, Tilman; Kalotai, Nicole; Amini, Anna M.; Haardt, Julia; Lehmann, Andreas; Schmidt, Annemarie; Buyken, AnetteLibreCat; Egert, Sarah; Ellinger, Sabine; Kroke, Anja; Lorkowski, Stefan; Louis, Sandrine
All
Abstract
<jats:title>Abstract</jats:title><jats:sec> <jats:title>Purpose</jats:title> <jats:p>It has been proposed that a higher habitual protein intake may increase cancer risk, possibly via upregulated insulin-like growth factor signalling. Since a systematic evaluation of human studies on protein intake and cancer risk based on a standardised assessment of systematic reviews (SRs) is lacking, we carried out an umbrella review of SRs on protein intake in relation to risks of different types of cancer.</jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>Following a pre-specified protocol (PROSPERO: CRD42018082395), we retrieved SRs on protein intake and cancer risk published before January 22th 2024, and assessed the methodological quality and outcome-specific certainty of the evidence using a modified version of AMSTAR 2 and NutriGrade, respectively. The overall certainty of evidence was rated according to predefined criteria.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>Ten SRs were identified, of which eight included meta-analyses. Higher total protein intake was not associated with risks of breast, prostate, colorectal, ovarian, or pancreatic cancer incidence. The methodological quality of the included SRs ranged from <jats:italic>critically low</jats:italic> (kidney cancer), <jats:italic>low</jats:italic> (pancreatic, ovarian and prostate cancer) and <jats:italic>moderate</jats:italic> (breast and prostate cancer) to <jats:italic>high</jats:italic> (colorectal cancer). The outcome-specific certainty of the evidence underlying the reported findings on protein intake and cancer risk ranged from <jats:italic>very low</jats:italic> (pancreatic, ovarian and prostate cancer) to <jats:italic>low</jats:italic> (colorectal, ovarian, prostate, and breast cancer). Animal and plant protein intakes were not associated with cancer risks either at a <jats:italic>low</jats:italic> (breast and prostate cancer) or <jats:italic>very low</jats:italic> (pancreatic and prostate cancer) outcome-specific certainty of the evidence. Overall, the evidence for the lack of an association between protein intake and (i) colorectal cancer risk and (ii) breast cancer risk was rated as <jats:italic>possible</jats:italic>. By contrast, the evidence underlying the other reported results was rated as <jats:italic>insufficient</jats:italic>.</jats:p> </jats:sec><jats:sec> <jats:title>Conclusion</jats:title> <jats:p>The present findings suggest that higher total protein intake may not be associated with the risk of colorectal and breast cancer, while conclusions on protein intake in relation to risks of other types of cancer are restricted due to <jats:italic>insufficient</jats:italic> evidence.</jats:p> </jats:sec>
Publishing Year
Journal Title
European Journal of Nutrition
LibreCat-ID

Cite this

Kühn T, Kalotai N, Amini AM, et al. Protein intake and cancer: an umbrella review of systematic reviews for the evidence-based guideline of the German Nutrition Society. European Journal of Nutrition. Published online 2024. doi:10.1007/s00394-024-03380-4
Kühn, T., Kalotai, N., Amini, A. M., Haardt, J., Lehmann, A., Schmidt, A., Buyken, A., Egert, S., Ellinger, S., Kroke, A., Lorkowski, S., Louis, S., Schulze, M. B., Schwingshackl, L., Siener, R., Stangl, G. I., Watzl, B., Zittermann, A., & Nimptsch, K. (2024). Protein intake and cancer: an umbrella review of systematic reviews for the evidence-based guideline of the German Nutrition Society. European Journal of Nutrition. https://doi.org/10.1007/s00394-024-03380-4
@article{Kühn_Kalotai_Amini_Haardt_Lehmann_Schmidt_Buyken_Egert_Ellinger_Kroke_et al._2024, title={Protein intake and cancer: an umbrella review of systematic reviews for the evidence-based guideline of the German Nutrition Society}, DOI={10.1007/s00394-024-03380-4}, journal={European Journal of Nutrition}, publisher={Springer Science and Business Media LLC}, author={Kühn, Tilman and Kalotai, Nicole and Amini, Anna M. and Haardt, Julia and Lehmann, Andreas and Schmidt, Annemarie and Buyken, Anette and Egert, Sarah and Ellinger, Sabine and Kroke, Anja and et al.}, year={2024} }
Kühn, Tilman, Nicole Kalotai, Anna M. Amini, Julia Haardt, Andreas Lehmann, Annemarie Schmidt, Anette Buyken, et al. “Protein Intake and Cancer: An Umbrella Review of Systematic Reviews for the Evidence-Based Guideline of the German Nutrition Society.” European Journal of Nutrition, 2024. https://doi.org/10.1007/s00394-024-03380-4.
T. Kühn et al., “Protein intake and cancer: an umbrella review of systematic reviews for the evidence-based guideline of the German Nutrition Society,” European Journal of Nutrition, 2024, doi: 10.1007/s00394-024-03380-4.
Kühn, Tilman, et al. “Protein Intake and Cancer: An Umbrella Review of Systematic Reviews for the Evidence-Based Guideline of the German Nutrition Society.” European Journal of Nutrition, Springer Science and Business Media LLC, 2024, doi:10.1007/s00394-024-03380-4.

Export

Marked Publications

Open Data LibreCat

Search this title in

Google Scholar