Sex-differences in autonomic and cardiovascular responses to multimodal therapy in Parkinson’s disease: a pilot study
F. Siche-Pantel, M. Mühlenberg, R. Buschfort, H. Michels, R. Jakobsmeyer, J. Oesterschlink, C. Reinsberger, BMC Neurology 25 (2025).
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Journal Article
| Published
| English
Author
Siche-Pantel, Franziska;
Mühlenberg, Manfred;
Buschfort, Rüdiger;
Michels, Heinke;
Jakobsmeyer, Rasmus;
Oesterschlink, Julian;
Reinsberger, Claus
Department
Abstract
<jats:title>Abstract</jats:title>
<jats:sec>
<jats:title>Background</jats:title>
<jats:p>Parkinson’s Disease (PD) bears a variety of sex differences and is associated with cardiovascular dysregulation (CDR). Variation in the routinely assessed standard parameters heart rate (HR) and blood pressure (BP) seem not well understood within the frame of sex-specific developments under therapy. Parameters of heart rate variability (RMSSD) and electrodermal activity (meanEDA) may assist the understanding of underlying autonomic developments. This pilot study aims to describe sex-specific cardiovascular and autonomic responses to a multimodal inpatient rehabilitation program in patients with PD.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Methods</jats:title>
<jats:p>Forty-one PD patients (24 male, 17 female) participated in a stationary, multimodal therapy intervention (MTI). Before and after MTI, HR, BP, RMSSD, and meanEDA were assessed in supine baseline (5 min of rest before orthostasis) and during supine adaption to rest (5 min of rest after orthostasis). Differences between baseline and adaption to rest as well as differences over time of MTI were calculated using Wilcoxon test; sex differences using Mann–Whitney-U test.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Results</jats:title>
<jats:p>Before MTI, women’s supine HR (<jats:italic>p</jats:italic> = .034*; d = .17) and BP (<jats:italic>p</jats:italic> = .015*, d = 0.4) were significantly higher during adaption to rest than during baseline. After MTI, women’s supine HR (<jats:italic>p</jats:italic> = .020*; d = .84) and BP (<jats:italic>p</jats:italic> = .022*, d = 0.5) during adaption to rest had decreased significantly. Men’s HR and BP remained constant and without differences between the supine conditions. RMSSD and meanEDA remained steady in both sexes.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Conclusion</jats:title>
<jats:p>The sex-specific responsiveness to MTI supports the concept of sex-sensitive therapeutic management for cardiovascular symptoms in PD. In both sexes, peripheral cardiovascular outcomes appeared not attributable to corresponding outcomes in autonomic regulation. Further examination of autonomic parameters could provide a foundation for developing therapeutic approaches that address central nervous system mechanisms.</jats:p>
<jats:p>The study was officially registered (08/2020). The data supporting the findings of this study are available under <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://apps.who.int/trialsearch/" ext-link-type="uri">http://apps.who.int/trialsearch/</jats:ext-link> under trial number <jats:italic>DRKS00022773.</jats:italic>
</jats:p>
</jats:sec>
Publishing Year
Journal Title
BMC Neurology
Volume
25
Issue
1
Article Number
253
ISSN
LibreCat-ID
Cite this
Siche-Pantel F, Mühlenberg M, Buschfort R, et al. Sex-differences in autonomic and cardiovascular responses to multimodal therapy in Parkinson’s disease: a pilot study. BMC Neurology. 2025;25(1). doi:10.1186/s12883-025-04281-7
Siche-Pantel, F., Mühlenberg, M., Buschfort, R., Michels, H., Jakobsmeyer, R., Oesterschlink, J., & Reinsberger, C. (2025). Sex-differences in autonomic and cardiovascular responses to multimodal therapy in Parkinson’s disease: a pilot study. BMC Neurology, 25(1), Article 253. https://doi.org/10.1186/s12883-025-04281-7
@article{Siche-Pantel_Mühlenberg_Buschfort_Michels_Jakobsmeyer_Oesterschlink_Reinsberger_2025, title={Sex-differences in autonomic and cardiovascular responses to multimodal therapy in Parkinson’s disease: a pilot study}, volume={25}, DOI={10.1186/s12883-025-04281-7}, number={1253}, journal={BMC Neurology}, publisher={Springer Science and Business Media LLC}, author={Siche-Pantel, Franziska and Mühlenberg, Manfred and Buschfort, Rüdiger and Michels, Heinke and Jakobsmeyer, Rasmus and Oesterschlink, Julian and Reinsberger, Claus}, year={2025} }
Siche-Pantel, Franziska, Manfred Mühlenberg, Rüdiger Buschfort, Heinke Michels, Rasmus Jakobsmeyer, Julian Oesterschlink, and Claus Reinsberger. “Sex-Differences in Autonomic and Cardiovascular Responses to Multimodal Therapy in Parkinson’s Disease: A Pilot Study.” BMC Neurology 25, no. 1 (2025). https://doi.org/10.1186/s12883-025-04281-7.
F. Siche-Pantel et al., “Sex-differences in autonomic and cardiovascular responses to multimodal therapy in Parkinson’s disease: a pilot study,” BMC Neurology, vol. 25, no. 1, Art. no. 253, 2025, doi: 10.1186/s12883-025-04281-7.
Siche-Pantel, Franziska, et al. “Sex-Differences in Autonomic and Cardiovascular Responses to Multimodal Therapy in Parkinson’s Disease: A Pilot Study.” BMC Neurology, vol. 25, no. 1, 253, Springer Science and Business Media LLC, 2025, doi:10.1186/s12883-025-04281-7.