Exercise-induced central and peripheral sympathetic activity in a community-based group of epilepsy patients differ from healthy controls
F. van den Bongard, J.K. Gowik, J. Coenen, R. Jakobsmeyer, C. Reinsberger, Experimental Brain Research 242 (2024) 1301–1310.
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Journal Article
| Published
| English
Author
van den Bongard, Franziska;
Gowik, Julia Kristin;
Coenen, Jessica;
Jakobsmeyer, Rasmus;
Reinsberger, Claus
Abstract
<jats:title>Abstract</jats:title><jats:p>Ictal and interictal activity within the autonomic nervous system is characterized by a sympathetic overshoot in people with epilepsy. This autonomic dysfunction is assumed to be driven by alterations in the central autonomic network. In this study, exercise-induced changes of the interrelation of central and peripheral autonomic activity in patients with epilepsy was assessed. 21 patients with epilepsy (16 seizure-free), and 21 healthy matched controls performed an exhaustive bicycle ergometer test. Immediately before and after the exercise test, resting state electroencephalography measurements (Brain Products GmbH, 128-channel actiCHamp) of 5 min were carried out to investigate functional connectivity assessed by phase locking value in source space for whole brain, central autonomic network and visual network. Additionally, 1-lead ECG (Brain products GmbH) was performed to analyze parasympathetic (root mean square of successive differences (RMSSD) of the heart rate variability) and sympathetic activity (electrodermal activity (meanEDA)). MeanEDA increased (<jats:italic>p</jats:italic> < 0.001) and RMSSD decreased (<jats:italic>p</jats:italic> < 0.001) from pre to post-exercise in both groups. Correlation coefficients of meanEDA and central autonomic network functional connectivity differed significantly between the groups (<jats:italic>p</jats:italic> = 0.004) after exercise. Both patients with epilepsy and normal control subjects revealed the expected physiological peripheral autonomic responses to acute exhaustive exercise, but alterations of the correlation between central autonomic and peripheral sympathetic activity may indicate a different sympathetic reactivity after exercise in patients with epilepsy. The clinical relevance of this finding and its modulators (seizures, anti-seizure medication, etc.) still needs to be elucidated.</jats:p>
Publishing Year
Journal Title
Experimental Brain Research
Volume
242
Issue
6
Page
1301-1310
LibreCat-ID
Cite this
van den Bongard F, Gowik JK, Coenen J, Jakobsmeyer R, Reinsberger C. Exercise-induced central and peripheral sympathetic activity in a community-based group of epilepsy patients differ from healthy controls. Experimental Brain Research. 2024;242(6):1301-1310. doi:10.1007/s00221-024-06792-0
van den Bongard, F., Gowik, J. K., Coenen, J., Jakobsmeyer, R., & Reinsberger, C. (2024). Exercise-induced central and peripheral sympathetic activity in a community-based group of epilepsy patients differ from healthy controls. Experimental Brain Research, 242(6), 1301–1310. https://doi.org/10.1007/s00221-024-06792-0
@article{van den Bongard_Gowik_Coenen_Jakobsmeyer_Reinsberger_2024, title={Exercise-induced central and peripheral sympathetic activity in a community-based group of epilepsy patients differ from healthy controls}, volume={242}, DOI={10.1007/s00221-024-06792-0}, number={6}, journal={Experimental Brain Research}, publisher={Springer Science and Business Media LLC}, author={van den Bongard, Franziska and Gowik, Julia Kristin and Coenen, Jessica and Jakobsmeyer, Rasmus and Reinsberger, Claus}, year={2024}, pages={1301–1310} }
Bongard, Franziska van den, Julia Kristin Gowik, Jessica Coenen, Rasmus Jakobsmeyer, and Claus Reinsberger. “Exercise-Induced Central and Peripheral Sympathetic Activity in a Community-Based Group of Epilepsy Patients Differ from Healthy Controls.” Experimental Brain Research 242, no. 6 (2024): 1301–10. https://doi.org/10.1007/s00221-024-06792-0.
F. van den Bongard, J. K. Gowik, J. Coenen, R. Jakobsmeyer, and C. Reinsberger, “Exercise-induced central and peripheral sympathetic activity in a community-based group of epilepsy patients differ from healthy controls,” Experimental Brain Research, vol. 242, no. 6, pp. 1301–1310, 2024, doi: 10.1007/s00221-024-06792-0.
van den Bongard, Franziska, et al. “Exercise-Induced Central and Peripheral Sympathetic Activity in a Community-Based Group of Epilepsy Patients Differ from Healthy Controls.” Experimental Brain Research, vol. 242, no. 6, Springer Science and Business Media LLC, 2024, pp. 1301–10, doi:10.1007/s00221-024-06792-0.
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