TiO2 nanoparticle coatings on glass surfaces for the selective trapping of leukemia cells from peripheral blood

J.A. Garcia Diosa, A. Gonzalez Orive, C. Weinberger, S. Schwiderek, S. Knust, M. Tiemann, G. Grundmeier, A. Keller, R.J. Camargo Amado, Journal of Biomedical Materials Research Part B: Applied Biomaterials 109 (2021) 2142–2153.

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Journal Article | Published | English
Author
Garcia Diosa, Jaime Andres; Gonzalez Orive, Alejandro; Weinberger, ChristianLibreCat; Schwiderek, Sabrina; Knust, Steffen; Tiemann, MichaelLibreCat ; Grundmeier, GuidoLibreCat; Keller, AdrianLibreCat ; Camargo Amado, Ruben Jesus
Abstract
Photodynamic therapy (PDT) using TiO2 nanoparticles has become an important alternative treatment for different types of cancer due to their high photocatalytic activity and high absorption of UV-A light. To potentiate this treatment, we have coated commercial glass plates with TiO2 nanoparticles prepared by the sol–gel method (TiO2-m), which exhibit a remarkable selectivity for the irreversible trapping of cancer cells. The physicochemical properties of the deposited TiO2-m nanoparticle coatings have been characterized by a number of complementary surface-analytical techniques and their interaction with leukemia and healthy blood cells were investigated. Scanning electron and atomic force microscopy verify the formation of a compact layer of TiO2-m nanoparticles. The particles are predominantly in the anatase phase and have hydroxyl-terminated surfaces as revealed by Raman, X-ray photoelectron, and infrared spectroscopy, as well as X-ray diffraction. We find that lymphoblastic leukemia cells adhere to the TiO2-m coating and undergo amoeboid-like migration, whereas lymphocytic cells show distinctly weaker interactions with the coating. This evidences the potential of this nanomaterial coating to selectively trap cancer cells and renders it a promising candidate for the development of future prototypes of PDT devices for the treatment of leukemia and other types of cancers with non-adherent cells.
Publishing Year
Journal Title
Journal of Biomedical Materials Research Part B: Applied Biomaterials
Volume
109
Page
2142–2153
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Garcia Diosa JA, Gonzalez Orive A, Weinberger C, et al. TiO2 nanoparticle coatings on glass surfaces for the selective trapping of leukemia cells from peripheral blood. Journal of Biomedical Materials Research Part B: Applied Biomaterials. 2021;109:2142–2153. doi:10.1002/jbm.b.34862
Garcia Diosa, J. A., Gonzalez Orive, A., Weinberger, C., Schwiderek, S., Knust, S., Tiemann, M., Grundmeier, G., Keller, A., & Camargo Amado, R. J. (2021). TiO2 nanoparticle coatings on glass surfaces for the selective trapping of leukemia cells from peripheral blood. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 109, 2142–2153. https://doi.org/10.1002/jbm.b.34862
@article{Garcia Diosa_Gonzalez Orive_Weinberger_Schwiderek_Knust_Tiemann_Grundmeier_Keller_Camargo Amado_2021, title={TiO2 nanoparticle coatings on glass surfaces for the selective trapping of leukemia cells from peripheral blood}, volume={109}, DOI={10.1002/jbm.b.34862}, journal={Journal of Biomedical Materials Research Part B: Applied Biomaterials}, author={Garcia Diosa, Jaime Andres and Gonzalez Orive, Alejandro and Weinberger, Christian and Schwiderek, Sabrina and Knust, Steffen and Tiemann, Michael and Grundmeier, Guido and Keller, Adrian and Camargo Amado, Ruben Jesus}, year={2021}, pages={2142–2153} }
Garcia Diosa, Jaime Andres, Alejandro Gonzalez Orive, Christian Weinberger, Sabrina Schwiderek, Steffen Knust, Michael Tiemann, Guido Grundmeier, Adrian Keller, and Ruben Jesus Camargo Amado. “TiO2 Nanoparticle Coatings on Glass Surfaces for the Selective Trapping of Leukemia Cells from Peripheral Blood.” Journal of Biomedical Materials Research Part B: Applied Biomaterials 109 (2021): 2142–2153. https://doi.org/10.1002/jbm.b.34862.
J. A. Garcia Diosa et al., “TiO2 nanoparticle coatings on glass surfaces for the selective trapping of leukemia cells from peripheral blood,” Journal of Biomedical Materials Research Part B: Applied Biomaterials, vol. 109, pp. 2142–2153, 2021, doi: 10.1002/jbm.b.34862.
Garcia Diosa, Jaime Andres, et al. “TiO2 Nanoparticle Coatings on Glass Surfaces for the Selective Trapping of Leukemia Cells from Peripheral Blood.” Journal of Biomedical Materials Research Part B: Applied Biomaterials, vol. 109, 2021, pp. 2142–2153, doi:10.1002/jbm.b.34862.

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